Anapc4 anaphase promoting complex subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anapc4provided by MGI
Official Full Name: anaphase promoting complex subunit 4provided by MGI
Primary source: MGI:MGI:1098673
See related: Ensembl:ENSMUSG00000029176 AllianceGenome:MGI:1098673
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APC4; D5Ertd249e; 2610306D21Rik
Summary: Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Is expressed in cervico-thoracic ganglion; dorsal root ganglion; prostate gland; testis; and thoracic ganglion. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 38.1), CNS E14 (RPKM 29.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 28.81 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (52991477..53024076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (52834135..52866734)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

D5Ertd249e (e-PCR), detects polymorphism
- UniSTS:167424

Homology

Homologs of the Anapc4 gene: The Anapc4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 496 organisms have orthologs with human gene Anapc4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of anaphase-promoting complex	ISO Inferred from Sequence Orthology more info
is_active_in nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anaphase-promoting complex subunit 4

Names: cyclosome subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024213.2 → NP_077175.1 anaphase-promoting complex subunit 4

See identical proteins and their annotated locations for NP_077175.1

Status: PROVISIONAL

Source sequence(s)

AC102766

Consensus CDS

CCDS19290.1

UniProtKB/Swiss-Prot

Q91W96, Q9CZZ0

UniProtKB/TrEMBL

Q3TM92

Related

ENSMUSP00000031072.8, ENSMUST00000031072.14

Conserved Domains (4) summary

pfam12894
Location:10 → 57

ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain

pfam12896
Location:232 → 431

ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

sd00039
Location:24 → 59

7WD40; WD40 repeat [structural motif]

cl02567
Location:26 → 115

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...