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SEC61A1 SEC61 translocon subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 29927, updated on 30-Aug-2020

Summary

Official Symbol
SEC61A1provided by HGNC
Official Full Name
SEC61 translocon subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:18276
See related
Ensembl:ENSG00000058262 MIM:609213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNFJ4; SEC61; HSEC61; SEC61A
Summary
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 81.0), placenta (RPKM 70.7) and 25 other tissues See more
Orthologs

Genomic context

See SEC61A1 in Genome Data Viewer
Location:
3q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (128052437..128071683)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127770402..127790526)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 12 Neighboring gene RNA, 5S ribosomal pseudogene 139 Neighboring gene uncharacterized LOC102723759 Neighboring gene CRISPRi-FlowFISH-validated RPN1 regulatory element Neighboring gene RUVBL1 antisense RNA 1 Neighboring gene RuvB like AAA ATPase 1 Neighboring gene RNA, U2 small nuclear 37, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env HIV-1 gp120 is identified to have a physical interaction with Sec61 alpha 1 subunit (SEC61A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with Sec61 alpha 1 subunit (SEC61A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify Sec61 alpha 1 subunit (SEC61A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cotranslational protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranslational protein targeting to endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
posttranslational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pronephric nephron development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting to ER ISS
Inferred from Sequence or Structural Similarity
more info
 
response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein transport protein Sec61 subunit alpha isoform 1
Names
SEC61 translocon alpha 1 subunit
Sec61 alpha 1 subunit
Sec61 alpha-1
protein transport protein SEC61 alpha subunit
protein transport protein Sec61 subunit alpha
sec61 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052786.1 RefSeqGene

    Range
    5069..24315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013336.4NP_037468.1  protein transport protein Sec61 subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_037468.1

    Status: REVIEWED

    Source sequence(s)
    AF084458, AK027423, AK027452
    Consensus CDS
    CCDS3046.1
    UniProtKB/Swiss-Prot
    P61619
    UniProtKB/TrEMBL
    B3KME8, B3KNF6
    Related
    ENSP00000243253.3, ENST00000243253.8
    Conserved Domains (1) summary
    PTZ00219
    Location:1471
    PTZ00219; Sec61 alpha subunit; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    128052437..128071683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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