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ALG5 ALG5 dolichyl-phosphate beta-glucosyltransferase [ Homo sapiens (human) ]

Gene ID: 29880, updated on 3-May-2020

Summary

Official Symbol
ALG5provided by HGNC
Official Full Name
ALG5 dolichyl-phosphate beta-glucosyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:20266
See related
Ensembl:ENSG00000120697 MIM:604565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA421P11.2
Summary
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in thyroid (RPKM 27.6), colon (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See ALG5 in Genome Data Viewer
Location:
13q13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (36949738..36999367, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37523907..37573504, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 28 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 5 Neighboring gene exosome component 8 Neighboring gene uncharacterized LOC105370165 Neighboring gene SPT20 homolog, SAGA complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichyl-phosphate beta-glucosyltransferase activity TAS
Traceable Author Statement
more info
 
oligosaccharyl transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
dolichyl-phosphate beta-glucosyltransferase
Names
Alg5, S. cerevisiae, homolog of
asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog
asparagine-linked glycosylation protein 5 homolog
dolP-glucosyltransferase
dolichyl phosphate glucosyltransferase
NP_001135836.1
NP_037470.1
XP_016876041.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142364.1NP_001135836.1  dolichyl-phosphate beta-glucosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001135836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.
    Source sequence(s)
    AK299085, BP246765, BU739112
    Consensus CDS
    CCDS45033.1
    UniProtKB/Swiss-Prot
    Q9Y673
    Related
    ENSP00000390533.1, ENST00000443765.5
    Conserved Domains (1) summary
    cd04188
    Location:69259
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
  2. NM_013338.5NP_037470.1  dolichyl-phosphate beta-glucosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_037470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL138706, BC012531, BP246765, BU739112
    Consensus CDS
    CCDS9361.1
    UniProtKB/Swiss-Prot
    Q9Y673
    Related
    ENSP00000239891.3, ENST00000239891.4
    Conserved Domains (1) summary
    cd04188
    Location:69289
    DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    36949738..36999367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020552.1XP_016876041.1  dolichyl-phosphate beta-glucosyltransferase isoform X1

RNA

  1. XR_001749540.2 RNA Sequence

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