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Cspg5 chondroitin sulfate proteoglycan 5 [ Mus musculus (house mouse) ]

Gene ID: 29873, updated on 11-Apr-2024

Summary

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Official Symbol
Cspg5provided by MGI
Official Full Name
chondroitin sulfate proteoglycan 5provided by MGI
Primary source
MGI:MGI:1352747
See related
Ensembl:ENSMUSG00000032482 AllianceGenome:MGI:1352747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngc; Caleb
Summary
This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]
Expression
Biased expression in frontal lobe adult (RPKM 51.3), cortex adult (RPKM 50.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110072851..110091644)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110243783..110262576)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene STARR-seq mESC enhancer starr_25255 Neighboring gene STARR-seq mESC enhancer starr_25257 Neighboring gene 4.5s RNA, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_25258 Neighboring gene predicted gene, 39429 Neighboring gene STARR-positive B cell enhancer ABC_E461 Neighboring gene microRNA 6236 Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C). Jüttner R, et al. Eur J Neurosci, 2013 Nov. PMID 23889129
  2. Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5. Cottet S, et al. Mol Vis, 2013. PMID 24265546, Free PMC Article
  3. Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice. Escher P, et al. Mol Vis, 2008. PMID 19050768, Free PMC Article
  4. The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. Brandt N, et al. EMBO J, 2007 May 2. PMID 17431398, Free PMC Article
  5. Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C. Aono S, et al. J Biol Chem, 2004 Nov 5. PMID 15331613

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CALEB is transiently required for synapse maturation in the cerebellum.
    Title: Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C).
  2. Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified.
    Title: Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5.
  3. During retinal degeneration in Rpe65-/- mice, neuroglycan C(NGC) expression is induced in neural retina, but not in retinal pigment epithelium, where NGC is expressed at highest levels.
    Title: Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice.
  4. PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
    Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
  5. there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
    Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
  6. phosphorylation and localization in lipid rafts
    Title: Phosphorylation of neuroglycan C, a brain-specific transmembrane chondroitin sulfate proteoglycan, and its localization in the lipid rafts.
  7. neuroglycan C is a novel component of midkine receptors involved in process elongation
    Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in glial cell projection elongation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chondroitin sulfate proteoglycan 5
Names
acidic leucine-rich EGF-like domain-containing brain protein
neuroglycan C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166273.1 → NP_001159745.1  chondroitin sulfate proteoglycan 5 isoform b precursor

    See identical proteins and their annotated locations for NP_001159745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform b), compared to isoform a. Isoform b is also known as NGC-III and mCALEBb. Variant 2 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.
    Source sequence(s)
    AC159372, AF461092, BC055736
    Consensus CDS
    CCDS52936.1
    UniProtKB/Swiss-Prot
    E9QN54, Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32
    Related
    ENSMUSP00000035058.6, ENSMUST00000035058.10
    Conserved Domains (2) summary
    pfam06566
    Location:33 → 273
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:447 → 565
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

  2. NM_013884.3 → NP_038912.3  chondroitin sulfate proteoglycan 5 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a), also known as NGC-I and mCALEBa. Variant 1 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.
    Source sequence(s)
    AC159372, AF133700, AF461090, BC055736
    Consensus CDS
    CCDS81085.1
    UniProtKB/Swiss-Prot
    Q71M36
    Related
    ENSMUSP00000143164.2, ENSMUST00000196060.5
    Conserved Domains (2) summary
    pfam06566
    Location:33 → 273
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:447 → 538
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110072851..110091644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q71M36.2 GenPept UniProtKB/Swiss-Prot:Q71M36

Gene LinkOut

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