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CSPG5 chondroitin sulfate proteoglycan 5 [ Homo sapiens (human) ]

Gene ID: 10675, updated on 25-Nov-2021

Summary

Official Symbol
CSPG5provided by HGNC
Official Full Name
chondroitin sulfate proteoglycan 5provided by HGNC
Primary source
HGNC:HGNC:2467
See related
Ensembl:ENSG00000114646 MIM:606775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGC
Summary
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Restricted expression toward brain (RPKM 49.7) See more
Orthologs
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Genomic context

See CSPG5 in Genome Data Viewer
Location:
3p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47562238..47580240, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47603728..47621730, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377074 Neighboring gene RNA, 7SL, cytoplasmic 870, pseudogene Neighboring gene Sharpr-MPRA regulatory region 12920 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 Neighboring gene small nucleolar RNA, C/D box 146 Neighboring gene HIGD2A pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glial cell projection elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular transport TAS
Traceable Author Statement
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in trans-synaptic signaling, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi-associated vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chondroitin sulfate proteoglycan 5
Names
acidic leucine-rich EGF-like domain-containing brain protein
chondroitin sulfate proteoglycan 5 (neuroglycan C)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029493.1 RefSeqGene

    Range
    5001..23003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206942.2NP_001193871.1  chondroitin sulfate proteoglycan 5 isoform 2

    See identical proteins and their annotated locations for NP_001193871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal segment compared to isoform 3.
    Source sequence(s)
    AC112512, AK294621, BU732090
    Consensus CDS
    CCDS56252.1
    UniProtKB/TrEMBL
    B7Z2E0
    Related
    ENSP00000392096.1, ENST00000456150.5
    Conserved Domains (2) summary
    pfam06566
    Location:1134
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:309400
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
  2. NM_001206943.2NP_001193872.1  chondroitin sulfate proteoglycan 5 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001193872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC112512, AF461089, BU732090
    Consensus CDS
    CCDS56253.1
    UniProtKB/Swiss-Prot
    O95196
    Related
    ENSP00000373244.2, ENST00000383738.6
    Conserved Domains (2) summary
    pfam06566
    Location:33272
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:447565
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
  3. NM_001206944.2NP_001193873.1  chondroitin sulfate proteoglycan 5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon compared to variant 3, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC112512, AF461087, BU732090
    Consensus CDS
    CCDS74930.1
    UniProtKB/Swiss-Prot
    O95196
    UniProtKB/TrEMBL
    A0A087WUT8
    Related
    ENSP00000478923.1, ENST00000610462.1
    Conserved Domains (2) summary
    pfam01683
    Location:359412
    EB; EB module
    pfam06566
    Location:33272
    Chon_Sulph_att; Chondroitin sulphate attachment domain
  4. NM_001206945.2NP_001193874.1  chondroitin sulfate proteoglycan 5 isoform 5

    See identical proteins and their annotated locations for NP_001193874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) is shorter at the N-terminus compared to isoform 3.
    Source sequence(s)
    AC112512, AK294621, BU732090
    UniProtKB/TrEMBL
    B7Z2E0
    Conserved Domains (2) summary
    pfam06566
    Location:1134
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:309427
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
  5. NM_006574.4NP_006565.2  chondroitin sulfate proteoglycan 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006565.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame segment compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AF461087, AW003890, BM674119, DB636494
    Consensus CDS
    CCDS2757.1
    UniProtKB/Swiss-Prot
    O95196
    Related
    ENSP00000264723.4, ENST00000264723.9
    Conserved Domains (2) summary
    pfam06566
    Location:33272
    Chon_Sulph_att; Chondroitin sulphate attachment domain
    pfam06567
    Location:447538
    Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    47562238..47580240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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