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TRPM5 transient receptor potential cation channel subfamily M member 5 [ Homo sapiens (human) ]

Gene ID: 29850, updated on 7-Jun-2020

Summary

Official Symbol
TRPM5provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily M member 5provided by HGNC
Primary source
HGNC:HGNC:14323
See related
Ensembl:ENSG00000070985 MIM:604600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTR1; LTRPC5
Summary
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]
Expression
Biased expression in duodenum (RPKM 1.1), testis (RPKM 1.1) and 8 other tissues See more
Orthologs

Genomic context

See TRPM5 in Genome Data Viewer
Location:
11p15.5
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (2403962..2423424, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2425745..2444275, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 93 enhancer Neighboring gene CD81 molecule Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene potassium voltage-gated channel subfamily Q member 1 Neighboring gene Sharpr-MPRA regulatory region 10946 Neighboring gene KCNQ1 opposite strand/antisense transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium activated cation channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 5
Names
LTrpC-5
MLSN1 and TRP-related
MLSN1- and TRP-related gene 1 protein
long transient receptor potential channel 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014555.3NP_055370.1  transient receptor potential cation channel subfamily M member 5

    See identical proteins and their annotated locations for NP_055370.1

    Status: REVIEWED

    Source sequence(s)
    AF177473, AJ270996
    Consensus CDS
    CCDS31340.1
    UniProtKB/Swiss-Prot
    Q9NZQ8
    Related
    ENSP00000155858.5, ENST00000155858.10
    Conserved Domains (1) summary
    COG0515
    Location:253342
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    2403962..2423424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017628.1XP_016873117.1  transient receptor potential cation channel subfamily M member 5 isoform X1

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