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SENP1 SUMO specific peptidase 1 [ Homo sapiens (human) ]

Gene ID: 29843, updated on 21-Oct-2018

Summary

Official Symbol
SENP1provided by HGNC
Official Full Name
SUMO specific peptidase 1provided by HGNC
Primary source
HGNC:HGNC:17927
See related
Ensembl:ENSG00000079387 MIM:612157; Vega:OTTHUMG00000169896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SuPr-2
Summary
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues See more
Orthologs

Genomic context

See SENP1 in Genome Data Viewer
Location:
12q13.11
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (48042893..48106308, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48436681..48500091, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369752 Neighboring gene collagen type II alpha 1 chain Neighboring gene uncharacterized LOC105369750 Neighboring gene ribosomal protein L37 pseudogene 19 Neighboring gene V-type proton ATPase subunit F pseudogene Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene phosphofructokinase, muscle Neighboring gene microRNA 6505 Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Processing and activation of SUMO, organism-specific biosystem (from REACTOME)
    Processing and activation of SUMO, organism-specific biosystemThe initial translation products of SUMO1, SUMO2, and SUMO3 are precursors that have extra amino acid residues at the C-terminus (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun ...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • SUMO is proteolytically processed, organism-specific biosystem (from REACTOME)
    SUMO is proteolytically processed, organism-specific biosystemSUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endopr...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
SUMO-specific isopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein desumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
regulation of definitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sentrin-specific protease 1
Names
SUMO1/sentrin specific peptidase 1
SUMO1/sentrin specific protease 1
sentrin/SUMO-specific protease SENP1
NP_001254523.1
NP_001254524.1
XP_006719424.1
XP_006719425.1
XP_011536546.1
XP_011536547.1
XP_016874718.1
XP_016874719.1
XP_016874720.1
XP_016874721.1
XP_016874722.1
XP_016874723.1
XP_016874724.1
XP_016874725.1
XP_016874726.1
XP_016874727.1
XP_016874728.1
XP_016874729.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267594.1NP_001254523.1  sentrin-specific protease 1

    See identical proteins and their annotated locations for NP_001254523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004801, AK312874, BX640784
    Consensus CDS
    CCDS44868.2
    UniProtKB/Swiss-Prot
    Q9P0U3
    UniProtKB/TrEMBL
    Q6N001
    Related
    ENSP00000447328.1, OTTHUMP00000242416, ENST00000549518.5, OTTHUMT00000406471
    Conserved Domains (1) summary
    cl23802
    Location:420642
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. NM_001267595.1NP_001254524.1  sentrin-specific protease 1

    See identical proteins and their annotated locations for NP_001254524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004801, BC045639, BX537920, BX640784
    Consensus CDS
    CCDS44868.2
    UniProtKB/Swiss-Prot
    Q9P0U3
    UniProtKB/TrEMBL
    Q6N001, Q7Z3G1
    Related
    ENSP00000394791.2, OTTHUMP00000242414, ENST00000448372.5, OTTHUMT00000406469
    Conserved Domains (1) summary
    cl23802
    Location:420642
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

  1. NR_051991.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004801, BX537920, BX640784
    Related
    ENST00000552189.5, OTTHUMT00000406468
  2. NR_051992.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004801, BX537920, BX640784

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    48042893..48106308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019237.1XP_016874726.1  sentrin-specific protease 1 isoform X8

  2. XM_006719362.2XP_006719425.1  sentrin-specific protease 1 isoform X9

    Conserved Domains (1) summary
    cl23802
    Location:221443
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  3. XM_017019233.2XP_016874722.1  sentrin-specific protease 1 isoform X7

  4. XM_017019239.2XP_016874728.1  sentrin-specific protease 1 isoform X9

    Conserved Domains (1) summary
    cl23802
    Location:221443
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  5. XM_017019236.1XP_016874725.1  sentrin-specific protease 1 isoform X8

  6. XM_017019235.1XP_016874724.1  sentrin-specific protease 1 isoform X7

  7. XM_017019232.1XP_016874721.1  sentrin-specific protease 1 isoform X4

  8. XM_011538244.3XP_011536546.1  sentrin-specific protease 1 isoform X5

    Conserved Domains (1) summary
    cl23802
    Location:439661
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  9. XM_017019229.2XP_016874718.1  sentrin-specific protease 1 isoform X1

  10. XM_006719361.3XP_006719424.1  sentrin-specific protease 1 isoform X3

    See identical proteins and their annotated locations for XP_006719424.1

    Conserved Domains (1) summary
    cl23802
    Location:452674
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  11. XM_011538245.3XP_011536547.1  sentrin-specific protease 1 isoform X6

    Conserved Domains (1) summary
    cl23802
    Location:436658
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  12. XM_017019238.2XP_016874727.1  sentrin-specific protease 1 isoform X9

    Conserved Domains (1) summary
    cl23802
    Location:221443
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  13. XM_017019240.2XP_016874729.1  sentrin-specific protease 1 isoform X10

  14. XM_017019234.2XP_016874723.1  sentrin-specific protease 1 isoform X7

  15. XM_017019231.2XP_016874720.1  sentrin-specific protease 1 isoform X4

  16. XM_017019230.2XP_016874719.1  sentrin-specific protease 1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014554.2: Suppressed sequence

    Description
    NM_014554.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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