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Senp1 SUMO1/sentrin specific peptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 223870, updated on 17-Jun-2024

Summary

Official Symbol
Senp1provided by MGI
Official Full Name
SUMO1/sentrin specific peptidase 1provided by MGI
Primary source
MGI:MGI:2445054
See related
Ensembl:ENSMUSG00000033075 AllianceGenome:MGI:2445054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
suPr-2; D15Ertd528e; 2310046A20Rik; E330036L07Rik
Summary
Enables SUMO-specific isopeptidase activity. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein desumoylation; and regulation of definitive erythrocyte differentiation. Predicted to be located in focal adhesion; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.4), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs
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Genomic context

See Senp1 in Genome Data Viewer
Location:
15 F1; 15 54.04 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97936625..97991625, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98038744..98093569, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536 Neighboring gene predicted gene, 41395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97898039-97898148 Neighboring gene STARR-seq mESC enhancer starr_39649 Neighboring gene predicted gene, 25668 Neighboring gene STARR-positive B cell enhancer ABC_E10879 Neighboring gene STARR-positive B cell enhancer ABC_E5514 Neighboring gene STARR-seq mESC enhancer starr_39650 Neighboring gene STARR-seq mESC enhancer starr_39651 Neighboring gene phosphofructokinase, muscle Neighboring gene STARR-seq mESC enhancer starr_39652 Neighboring gene STARR-seq mESC enhancer starr_39654 Neighboring gene ankyrin repeat and SOCS box-containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E5515 Neighboring gene coiled-coil domain containing 184

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27975

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deSUMOylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deSUMOylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein desumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein desumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sentrin-specific protease 1
Names
SUMO-1 protease 2
SUMO1/sentrin specific protease 1
sentrin/SUMO-specific protease SENP1
NP_001366502.1
NP_659100.1
XP_006520943.1
XP_006520945.1
XP_006520946.1
XP_006520947.1
XP_030104385.1
XP_030104386.1
XP_036015277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379573.1NP_001366502.1  sentrin-specific protease 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113444
    Conserved Domains (2) summary
    PRK04863
    Location:381475
    mukB; chromosome partition protein MukB
    cl23802
    Location:448670
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. NM_144851.5NP_659100.1  sentrin-specific protease 1 isoform 2

    See identical proteins and their annotated locations for NP_659100.1

    Status: VALIDATED

    Source sequence(s)
    AK009838, AK028565, AK054521, AW490919, BF453574, CX203962
    Consensus CDS
    CCDS49717.1
    UniProtKB/Swiss-Prot
    P59110, Q8BTV5, Q8BZF1
    Related
    ENSMUSP00000046598.9, ENSMUST00000044189.16
    Conserved Domains (1) summary
    cl23802
    Location:416638
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97936625..97991625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520882.5XP_006520945.1  sentrin-specific protease 1 isoform X2

    UniProtKB/TrEMBL
    M0QWX4
    Related
    ENSMUSP00000138056.2, ENSMUST00000180657.2
    Conserved Domains (2) summary
    PRK04863
    Location:375469
    mukB; chromosome partition protein MukB
    cl23802
    Location:442664
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. XM_006520884.5XP_006520947.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
  3. XM_006520883.3XP_006520946.1  sentrin-specific protease 1 isoform X3

    Conserved Domains (2) summary
    COG5160
    Location:285524
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    PRK04863
    Location:233327
    mukB; chromosome partition protein MukB
  4. XM_006520880.3XP_006520943.1  sentrin-specific protease 1 isoform X1

    Conserved Domains (2) summary
    PRK04863
    Location:407501
    mukB; chromosome partition protein MukB
    cl23802
    Location:474696
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  5. XM_030248526.1XP_030104386.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
  6. XM_030248525.1XP_030104385.1  sentrin-specific protease 1 isoform X3

    Conserved Domains (2) summary
    COG5160
    Location:285524
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    PRK04863
    Location:233327
    mukB; chromosome partition protein MukB
  7. XM_036159384.1XP_036015277.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]