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TFCP2L1 transcription factor CP2 like 1 [ Homo sapiens (human) ]

Gene ID: 29842, updated on 18-Nov-2025
Official Symbol
TFCP2L1provided by HGNC
Official Full Name
transcription factor CP2 like 1provided by HGNC
Primary source
HGNC:HGNC:17925
See related
Ensembl:ENSG00000115112 MIM:609785; AllianceGenome:HGNC:17925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LBP9; CRTR1; LBP-9
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in kidney (RPKM 25.1), salivary gland (RPKM 23.9) and 10 other tissues See more
Orthologs
mouse all
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See TFCP2L1 in Genome Data Viewer
Location:
2q14.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (121216587..121285202, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (121651879..121720501, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (121974163..122042778, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121828403-121828966 Neighboring gene VISTA enhancer hs522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121889594-121890232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121890689-121891190 Neighboring gene uncharacterized LOC105373588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121954553-121955451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121957297-121957798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121957799-121958298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121972077-121972577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121974845-121975346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122003829-122004330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122091915-122092848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122094177-122094762 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122109698-122109870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16463 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122140378-122140878 Neighboring gene cytoplasmic linker associated protein 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:122187059-122188258 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122205649-122205872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16465 Neighboring gene CLASP1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. [Functional state of the stomach in patients with diffuse toxic goiter and hypothyroidism]. Mukhamadieva GA. Vrach Delo, 1975 Jun. PMID 1173954
  2. Tfcp2l1 safeguards the maintenance of human embryonic stem cell self-renewal. Sun H, et al. J Cell Physiol, 2018 Sep. PMID 29323720
  3. The Transcription Factor TFCP2L1 is Associated with Myelination via miR708-5p Regulation in the Peripheral Nerve System. Sohn EJ, et al. Neurochem Res, 2022 Feb. PMID 34581937
  4. The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells. Wang X, et al. J Biol Chem, 2019 Apr 12. PMID 30782842, Free PMC Article
  5. Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis. Heo J, et al. EMBO Mol Med, 2020 Jan 9. PMID 31709755, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance.
    Title: SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance.
  2. The Transcription Factor TFCP2L1 is Associated with Myelination via miR708-5p Regulation in the Peripheral Nerve System.
    Title: The Transcription Factor TFCP2L1 is Associated with Myelination via miR708-5p Regulation in the Peripheral Nerve System.
  3. The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
    Title: The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
  4. Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.
    Title: Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.
  5. Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis.
    Title: Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis.
  6. These findings indicate that TFCP2L1 functions differently in naive and primed pluripotency, insights that may help elucidate the different states of pluripotency.
    Title: The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
  7. these findings reveal the unique and crucial role of Tfcp2l1 in the determination of human embryonic stem cell fate.
    Title: Tfcp2l1 safeguards the maintenance of human embryonic stem cell self-renewal.
  8. Studies reveal that TFCP2, TFCP2L1, UBP1 belong to a transcription factors subfamily and involved in various aspects of cancer types and development as either proto-oncogenes or tumor suppressors. They can directly interact with each other; TFCP2, TFCP2L1 and UBP1 can form heteromeric DNA-binding complexes. In addition, TFCP2L1 can modulate the activity of TFCP2 and UBP1. [review]
    Title: TFCP2/TFCP2L1/UBP1 transcription factors in cancer.
  9. Study show that CRTR-1 is generally an activator of transcription and that it modulates the activity of other family members, CP2, NF2d9 and altNF2d9, in a cell specific manner.
    Title: Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation.
  10. LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity.
    Title: LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoplasm organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within salivary gland development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor CP2-like protein 1
Names
CP2-related transcriptional repressor 1
CRTR-1
transcription factor LBP-9

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014553.3 → NP_055368.1  transcription factor CP2-like protein 1

    See identical proteins and their annotated locations for NP_055368.1

    Status: VALIDATED

    Source sequence(s)
    AC013399, AC079988, BC064698, BM055156
    Consensus CDS
    CCDS2134.1
    UniProtKB/Swiss-Prot
    Q4ZG43, Q9NZI6
    Related
    ENSP00000263707.5, ENST00000263707.6
    Conserved Domains (2) summary
    cd09590
    Location:310 → 376
    SAM_LBP9; SAM domain of LBP9 transcriptional factors
    pfam04516
    Location:34 → 237
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    121216587..121285202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003902.2 → XP_016859391.1  transcription factor CP2-like protein 1 isoform X1

    Related
    ENSP00000549640.1, ENST00000879581.1

  2. XM_047444020.1 → XP_047299976.1  transcription factor CP2-like protein 1 isoform X5

  3. XM_047444021.1 → XP_047299977.1  transcription factor CP2-like protein 1 isoform X5

  4. XM_017003903.1 → XP_016859392.1  transcription factor CP2-like protein 1 isoform X2

  5. XM_017003905.2 → XP_016859394.1  transcription factor CP2-like protein 1 isoform X4

    UniProtKB/TrEMBL
    Q5JV87

  6. XM_017003904.2 → XP_016859393.1  transcription factor CP2-like protein 1 isoform X3

    UniProtKB/TrEMBL
    Q5JV87
    Conserved Domains (1) summary
    pfam04516
    Location:34 → 237
    CP2; CP2 transcription factor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    121651879..121720501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341547.1 → XP_054197522.1  transcription factor CP2-like protein 1 isoform X1

  2. XM_054341551.1 → XP_054197526.1  transcription factor CP2-like protein 1 isoform X5

  3. XM_054341552.1 → XP_054197527.1  transcription factor CP2-like protein 1 isoform X5

  4. XM_054341548.1 → XP_054197523.1  transcription factor CP2-like protein 1 isoform X2

  5. XM_054341550.1 → XP_054197525.1  transcription factor CP2-like protein 1 isoform X4

    UniProtKB/TrEMBL
    Q5JV87

  6. XM_054341549.1 → XP_054197524.1  transcription factor CP2-like protein 1 isoform X3

    UniProtKB/TrEMBL
    Q5JV87
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZI6.1 GenPept UniProtKB/Swiss-Prot:Q9NZI6

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