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Tfcp2l1 transcription factor CP2-like 1 [ Mus musculus (house mouse) ]

Gene ID: 81879, updated on 12-May-2024

Summary

Official Symbol
Tfcp2l1provided by MGI
Official Full Name
transcription factor CP2-like 1provided by MGI
Primary source
MGI:MGI:2444691
See related
Ensembl:ENSMUSG00000026380 AllianceGenome:MGI:2444691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cp2l1; LBP-9; Crtr-1; Tcfcp2l1; 1810030F05Rik; 4932442M07Rik; D930018N21Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; epithelial cell maturation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in early conceptus; genitourinary system; heart; and limb. Orthologous to human TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 29.5), colon adult (RPKM 24.0) and 8 other tissues See more
Orthologs
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Genomic context

See Tfcp2l1 in Genome Data Viewer
Location:
1 E2.3; 1 52.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118555646..118612898)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118627923..118685168)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060B14 gene Neighboring gene CLIP associating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120355892-120356193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:120356261-120356370 Neighboring gene predicted gene, 26080 Neighboring gene STARR-seq mESC enhancer starr_01983 Neighboring gene STARR-seq mESC enhancer starr_01987 Neighboring gene STARR-seq mESC enhancer starr_01991 Neighboring gene STARR-seq mESC enhancer starr_01996 Neighboring gene predicted gene, 23497 Neighboring gene STARR-seq mESC enhancer starr_01999 Neighboring gene GLI-Kruppel family member GLI2 Neighboring gene predicted gene, 51642 Neighboring gene microRNA 6346 Neighboring gene STARR-seq mESC enhancer starr_02009 Neighboring gene STARR-seq mESC enhancer starr_02012 Neighboring gene STARR-seq mESC enhancer starr_02016 Neighboring gene predicted gene, 41934

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
transcription factor CP2-like protein 1
Names
CP2-related transcriptional repressor 1
Tcfcp2-related transcriptional repressor 1
transcription repressor CRTR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023755.2NP_076244.2  transcription factor CP2-like protein 1

    See identical proteins and their annotated locations for NP_076244.2

    Status: VALIDATED

    Source sequence(s)
    AC109271, AK143960, BC116663, BY707692, CF621828
    Consensus CDS
    CCDS35691.1
    UniProtKB/Swiss-Prot
    Q14AW3, Q3UNW5, Q99PF2
    Related
    ENSMUSP00000027629.9, ENSMUST00000027629.10
    Conserved Domains (2) summary
    cd09590
    Location:310376
    SAM_LBP9; SAM domain of LBP9 transcriptional factors
    pfam04516
    Location:34237
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    118555646..118612898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529961.3XP_006530024.1  transcription factor CP2-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd09590
    Location:259325
    SAM_LBP9; SAM domain of LBP9 transcriptional factors
    pfam04516
    Location:31186
    CP2; CP2 transcription factor