Tfcp2l1 transcription factor CP2-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfcp2l1provided by MGI
Official Full Name: transcription factor CP2-like 1provided by MGI
Primary source: MGI:MGI:2444691
See related: Ensembl:ENSMUSG00000026380 AllianceGenome:MGI:2444691
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cp2l1; LBP-9; Crtr-1; Tcfcp2l1; 1810030F05Rik; 4932442M07Rik; D930018N21Rik
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; epithelial cell maturation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in early conceptus; genitourinary system; heart; and limb. Orthologous to human TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 29.5), colon adult (RPKM 24.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 E2.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (118555646..118612898)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (118627923..118685168)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naive pluripotent stem cells in vivo and in vitro.
Title: Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro.
MK2 promotes Tfcp2l1 degradation via beta-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
Title: MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
Title: The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
These findings indicate that TFCP2L1 functions differently in naive and primed pluripotency, insights that may help elucidate the different states of pluripotency.
Title: The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
Thus, Tfcp2l1 is a critical regulator of intercalated cell-principal cell patterning in kidney collecting ducts, acting cell-autonomously in intercalated cells, and non-cell-autonomously in principal cells.
Title: Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.
TFCP2L1 depends on its N-terminus and CP2-like domain to maintain the undifferentiated state of mouse embryonic stem cells.
Title: TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1.
we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM-like domain. We also found that homo-oligomerization of SAM-like domain is dependent on the concentration of the proteins.
Title: Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells.
study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling.
Title: Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency.
Tfcp2l1 is at the intersection of LIF- and 2i-mediated self-renewal pathways and plays a critical role in maintaining embryonic stem cell identity.
Title: Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1.
Tfcp2l1 is the principal bridge between LIF/Stat3 input and the transcription factor core of naive pluripotency.
Title: Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124523 (e-PCR)
- UniSTS:161345

M-09981 (e-PCR)
- UniSTS:186241

PMC304100P4 (e-PCR)
- UniSTS:272529

NoName (e-PCR)
- UniSTS:234191

NoName (e-PCR)
- UniSTS:234192

Homology

Homologs of the Tfcp2l1 gene: The Tfcp2l1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 336 organisms have orthologs with human gene Tfcp2l1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasm organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: transcription factor CP2-like protein 1

Names: CP2-related transcriptional repressor 1; Tcfcp2-related transcriptional repressor 1; transcription repressor CRTR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023755.2 → NP_076244.2 transcription factor CP2-like protein 1

See identical proteins and their annotated locations for NP_076244.2

Status: VALIDATED

Source sequence(s)

AC109271, AK143960, BC116663, BY707692, CF621828

Consensus CDS

CCDS35691.1

UniProtKB/Swiss-Prot

Q3UNW5, Q99PF2

UniProtKB/TrEMBL

A0A8C6GQS5

Related

ENSMUSP00000027629.9, ENSMUST00000027629.10

Conserved Domains (2) summary

cd09590
Location:310 → 376

SAM_LBP9; SAM domain of LBP9 transcriptional factors

pfam04516
Location:34 → 237

CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

118555646..118612898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529961.3 → XP_006530024.1 transcription factor CP2-like protein 1 isoform X1

Conserved Domains (2) summary

cd09590
Location:259 → 325

SAM_LBP9; SAM domain of LBP9 transcriptional factors

pfam04516
Location:31 → 186

CP2; CP2 transcription factor