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Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

Gene ID: 29811, updated on 5-Mar-2019

Summary

Official Symbol
Ndrg2provided by MGI
Official Full Name
N-myc downstream regulated gene 2provided by MGI
Primary source
MGI:MGI:1352498
See related
Ensembl:ENSMUSG00000004558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr2; SYLD; AI182517; AU040374
Expression
Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
Orthologs

Genomic context

See Ndrg2 in Genome Data Viewer
Location:
14; 14 C1
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (51905271..51914092, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (52524946..52533163, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
regulation of platelet-derived growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein NDRG2
Names
N-myc downstream regulated 2
N-myc downstream-regulated gene 2 protein
protein Ndr2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145959.1NP_001139431.1  protein NDRG2 isoform 2

    See identical proteins and their annotated locations for NP_001139431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AA014560, AI837300, AK158900, BB848819
    Consensus CDS
    CCDS49486.1
    UniProtKB/Swiss-Prot
    Q9QYG0
    Related
    ENSMUSP00000107259.3, ENSMUST00000111632.4
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  2. NM_001360264.1NP_001347193.1  protein NDRG2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
  3. NM_001360265.1NP_001347194.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  4. NM_001360266.1NP_001347195.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY131195, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  5. NM_001360267.1NP_001347196.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  6. NM_001360268.1NP_001347197.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  7. NM_001360269.1NP_001347198.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI837300, AK003364, BY280379, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  8. NM_001360270.1NP_001347199.1  protein NDRG2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY280379, CN539169, CX239542
  9. NM_001360271.1NP_001347200.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  10. NM_001360272.1NP_001347201.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY280379, CN539169, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  11. NM_001360273.1NP_001347202.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  12. NM_001360274.1NP_001347203.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  13. NM_001360276.1NP_001347205.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BU057240, BY298122, CN539169, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  14. NM_013864.2NP_038892.1  protein NDRG2 isoform 1

    See identical proteins and their annotated locations for NP_038892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represent the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AB033921, AI837300, AK173136, BB848819
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q9QYG0
    Related
    ENSMUSP00000004673.7, ENSMUST00000004673.14
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    51905271..51914092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519103.1XP_006519166.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  2. XM_006519105.2XP_006519168.1  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  3. XM_017316051.1XP_017171540.1  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  4. XM_017316046.1XP_017171535.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  5. XM_017316049.1XP_017171538.1  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  6. XM_017316050.1XP_017171539.1  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  7. XM_017316045.1XP_017171534.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  8. XM_006519099.3XP_006519162.2  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  9. XM_006519098.3XP_006519161.2  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  10. XM_006519104.3XP_006519167.1  protein NDRG2 isoform X2

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  11. XM_017316047.1XP_017171536.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  12. XM_017316052.1XP_017171541.1  protein NDRG2 isoform X4

  13. XM_017316048.1XP_017171537.1  protein NDRG2 isoform X3

Reference GRCm38.p4 129X1/SvJ

Genomic

  1. NT_096797.1 Reference GRCm38.p4 129X1/SvJ

    Range
    35622..43850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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