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Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

Gene ID: 29811, updated on 10-Mar-2024

Summary

Official Symbol
Ndrg2provided by MGI
Official Full Name
N-myc downstream regulated gene 2provided by MGI
Primary source
MGI:MGI:1352498
See related
Ensembl:ENSMUSG00000004558 AllianceGenome:MGI:1352498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr2; SYLD
Summary
Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
Orthologs
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Genomic context

See Ndrg2 in Genome Data Viewer
Location:
14 C2; 14 26.72 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52142738..52151463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51905271..51914004, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein NDRG2
Names
N-myc downstream regulated 2
N-myc downstream-regulated gene 2 protein
protein Ndr2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145959.2NP_001139431.1  protein NDRG2 isoform 2

    See identical proteins and their annotated locations for NP_001139431.1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    UniProtKB/Swiss-Prot
    Q9QYG0
    Related
    ENSMUSP00000107259.4, ENSMUST00000111632.5
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  2. NM_001360264.2NP_001347193.1  protein NDRG2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Conserved Domains (1) summary
    pfam03096
    Location:43321
    Ndr; Ndr family
  3. NM_001360265.2NP_001347194.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  4. NM_001360266.2NP_001347195.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  5. NM_001360267.2NP_001347196.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  6. NM_001360268.2NP_001347197.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  7. NM_001360269.2NP_001347198.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  8. NM_001360270.2NP_001347199.1  protein NDRG2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Conserved Domains (1) summary
    pfam03096
    Location:29307
    Ndr; Ndr family
  9. NM_001360271.2NP_001347200.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  10. NM_001360272.2NP_001347201.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  11. NM_001360273.2NP_001347202.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  12. NM_001360274.2NP_001347203.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  13. NM_001360276.2NP_001347205.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS49486.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  14. NM_001424691.1NP_001411620.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
  15. NM_001424692.1NP_001411621.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
  16. NM_001424693.1NP_001411622.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
  17. NM_001424694.1NP_001411623.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087
  18. NM_001424695.1NP_001411624.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
  19. NM_001424696.1NP_001411625.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
  20. NM_001424697.1NP_001411626.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
  21. NM_001424698.1NP_001411627.1  protein NDRG2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125087
  22. NM_001424699.1NP_001411628.1  protein NDRG2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125087
  23. NM_001424700.1NP_001411629.1  protein NDRG2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125087
  24. NM_001424701.1NP_001411630.1  protein NDRG2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125087
  25. NM_013864.3NP_038892.1  protein NDRG2 isoform 1

    See identical proteins and their annotated locations for NP_038892.1

    Status: VALIDATED

    Source sequence(s)
    AC125087
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Related
    ENSMUSP00000004673.8, ENSMUST00000004673.15
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52142738..52151463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158660.1XP_036014553.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  2. XM_036158662.1XP_036014555.1  protein NDRG2 isoform X2

    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family