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Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

Gene ID: 29811, updated on 19-Feb-2023

Summary

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Official Symbol
Ndrg2provided by MGI
Official Full Name
N-myc downstream regulated gene 2provided by MGI
Primary source
MGI:MGI:1352498
See related
Ensembl:ENSMUSG00000004558 AllianceGenome:MGI:1352498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr2; SYLD
Summary
Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and respiratory system. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ndrg2 in Genome Data Viewer
Location:
14; 14 C2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52142728..52151461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51905271..51914004, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions. Xu J, et al. J Neuroinflammation, 2022 Dec 26. PMID 36572898, Free PMC Article
  2. N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury. Wang J, et al. Mol Neurobiol, 2022 Aug. PMID 35622273
  3. Abnormal social behavior and altered gene expression in mice lacking NDRG2. Takarada-Iemata M, et al. Neurosci Lett, 2021 Jan 19. PMID 33359046
  4. Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo. Mir BA, et al. Exp Physiol, 2020 Aug. PMID 32468595
  5. Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling. Zhou J, et al. Brain Res, 2020 Feb 15. PMID 31843625

See all (95) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
    Title: Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
  2. Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
    Title: Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.
  3. N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
    Title: N-myc Downstream-Regulated Gene 2 (Ndrg2): A Critical Mediator of Estrogen-Induced Neuroprotection Against Cerebral Ischemic Injury.
  4. Transcription factor Kruppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1beta-induced chondrocyte inflammatory injury and extracellular matrix degradation.
    Title: Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation.
  5. Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
    Title: Long noncoding RNA MIR22HG promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-125a-5p that targets N-Myc downstream-regulated gene 2 in late-onset hypogonadism.
  6. Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
    Title: Overexpression of NDRG2 in skeletal muscle does not ameliorate the effects of stress in vivo.
  7. NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
    Title: NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.
  8. NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
    Title: NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
  9. NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake.
    Title: NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake.
  10. Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-kappaB/GLT1 signaling.
    Title: Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of platelet-derived growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein NDRG2
Names
N-myc downstream regulated 2
N-myc downstream-regulated gene 2 protein
protein Ndr2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145959.1 → NP_001139431.1  protein NDRG2 isoform 2

    See identical proteins and their annotated locations for NP_001139431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AA014560, AI837300, AK158900, BB848819
    Consensus CDS
    CCDS49486.1
    UniProtKB/Swiss-Prot
    Q9QYG0
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Related
    ENSMUSP00000107259.4, ENSMUST00000111632.5
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  2. NM_001360264.1 → NP_001347193.1  protein NDRG2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:43 → 321
    Ndr; Ndr family

  3. NM_001360265.1 → NP_001347194.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  4. NM_001360266.1 → NP_001347195.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY131195, CX123178, CX239542
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  5. NM_001360267.1 → NP_001347196.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  6. NM_001360268.1 → NP_001347197.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CX123178, CX239542
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  7. NM_001360269.1 → NP_001347198.1  protein NDRG2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI837300, AK003364, BY280379, CX123178, CX239542
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  8. NM_001360270.1 → NP_001347199.1  protein NDRG2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY280379, CN539169, CX239542
    Conserved Domains (1) summary
    pfam03096
    Location:29 → 307
    Ndr; Ndr family

  9. NM_001360271.1 → NP_001347200.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Consensus CDS
    CCDS49486.1
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  10. NM_001360272.1 → NP_001347201.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BY280379, CN539169, CX239542
    Consensus CDS
    CCDS49486.1
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  11. NM_001360273.1 → NP_001347202.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Consensus CDS
    CCDS49486.1
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  12. NM_001360274.1 → NP_001347203.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, CN539169, CX123178, CX239542
    Consensus CDS
    CCDS49486.1
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  13. NM_001360276.1 → NP_001347205.1  protein NDRG2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125087, AI837300, AK003364, BU057240, BY298122, CN539169, CX239542
    Consensus CDS
    CCDS49486.1
    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  14. NM_013864.2 → NP_038892.1  protein NDRG2 isoform 1

    See identical proteins and their annotated locations for NP_038892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represent the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AB033921, AI837300, AK173136, BB848819
    Consensus CDS
    CCDS27047.1
    UniProtKB/Swiss-Prot
    Q8C661, Q9QYG0
    UniProtKB/TrEMBL
    A0A8C6HU49
    Related
    ENSMUSP00000004673.8, ENSMUST00000004673.15
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    52142728..52151461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158660.1 → XP_036014553.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family

  2. XM_036158662.1 → XP_036014555.1  protein NDRG2 isoform X2

    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  3. XM_036158663.1 → XP_036014556.1  protein NDRG2 isoform X2

    UniProtKB/TrEMBL
    A0A8C6HVG6
    Conserved Domains (1) summary
    pfam03096
    Location:26 → 304
    Ndr; Ndr family

  4. XM_036158661.1 → XP_036014554.1  protein NDRG2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C661
    UniProtKB/TrEMBL
    A0A8C6HU49
    Conserved Domains (1) summary
    pfam03096
    Location:40 → 318
    Ndr; Ndr family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYG0.1 GenPept UniProtKB/Swiss-Prot:Q9QYG0

Gene LinkOut

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