Format

Send to:

Choose Destination

NDRG2 NDRG family member 2 [ Homo sapiens (human) ]

Gene ID: 57447, updated on 17-May-2020

Summary

Official Symbol
NDRG2provided by HGNC
Official Full Name
NDRG family member 2provided by HGNC
Primary source
HGNC:HGNC:14460
See related
Ensembl:ENSG00000165795 MIM:605272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYLD
Summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Expression
Broad expression in salivary gland (RPKM 217.5), brain (RPKM 177.5) and 19 other tissues See more
Orthologs

Genomic context

See NDRG2 in Genome Data Viewer
Location:
14q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21016763..21070872, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21484922..21539098, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929718 Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 member 2 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene zinc finger protein 219 Neighboring gene transmembrane protein 253 Neighboring gene cytoskeleton associated protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25522, KIAA1248, DKFZp781G1938

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of platelet-derived growth factor production IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein NDRG2
Names
N-myc downstream regulator 2
N-myc downstream-regulated gene 2 protein
NDR1-related protein NDR2
cytoplasmic protein Ndr1
syld709613 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282211.1NP_001269140.1  protein NDRG2 isoform c

    See identical proteins and their annotated locations for NP_001269140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate upstream exon in place of the first two exons and lacks an alternate in-frame internal exon compared to variant 1. The resulting isoform (c) is longer at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AK293514, BF341160, BX248031
    Consensus CDS
    CCDS61386.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000385889.3, ENST00000403829.7
    Conserved Domains (2) summary
    COG0596
    Location:115309
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:36314
    Ndr; Ndr family
  2. NM_001282212.1NP_001269141.1  protein NDRG2 isoform d

    See identical proteins and their annotated locations for NP_001269141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) lacks two alternate internal segments compared to isoform a.
    Source sequence(s)
    BF341160, BX247987, BX248031, DA065447
    Consensus CDS
    CCDS73613.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380943.2, ENST00000397844.6
    Conserved Domains (2) summary
    COG0596
    Location:105283
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:26288
    Ndr; Ndr family
  3. NM_001282213.1NP_001269142.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_001269142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and lacks an alternate in-frame internal exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 all encode the same isoform (b).
    Source sequence(s)
    AK057847, BF341160, BX248031, BX647748
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000452306.1, ENST00000553503.5
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  4. NM_001282214.1NP_001269143.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_001269143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and lacks an alternate in-frame internal exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 all encode the same isoform (b).
    Source sequence(s)
    BF341160, BX248031, CR749252
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000452038.1, ENST00000555158.5
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  5. NM_001282215.2NP_001269144.1  protein NDRG2 isoform e

    See identical proteins and their annotated locations for NP_001269144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (e) lacks an alternate segment compared to isoform a.
    Source sequence(s)
    AF304051, AL161668, BC011240, BF341160, BX248031
    Consensus CDS
    CCDS61384.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380945.2, ENST00000397847.6
    Conserved Domains (2) summary
    COG0596
    Location:119302
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:40307
    Ndr; Ndr family
  6. NM_001282216.1NP_001269145.1  protein NDRG2 isoform f

    See identical proteins and their annotated locations for NP_001269145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate splice junction at the 5' end of a coding exon, and initiates translation from a downstream AUG, compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK057847, AK090657, BF341160, BX248031
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000452216.1, ENST00000554104.5
    Conserved Domains (2) summary
    COG0596
    Location:59253
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:21258
    Ndr; Ndr family
  7. NM_001320329.1NP_001307258.1  protein NDRG2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 7 and 15 encode the same isoform (a).
    Source sequence(s)
    AF304051, AK096999
    Consensus CDS
    CCDS9565.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000451712.1, ENST00000556147.5
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  8. NM_001354558.1NP_001341487.1  protein NDRG2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Conserved Domains (1) summary
    pfam03096
    Location:40336
    Ndr; Ndr family
  9. NM_001354559.2NP_001341488.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  10. NM_001354560.1NP_001341489.1  protein NDRG2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Conserved Domains (1) summary
    pfam03096
    Location:26293
    Ndr; Ndr family
  11. NM_001354561.2NP_001341490.1  protein NDRG2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9564.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  12. NM_001354562.2NP_001341491.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  13. NM_001354564.1NP_001341493.1  protein NDRG2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Related
    ENSP00000452362.1, ENST00000556974.5
    Conserved Domains (1) summary
    pfam03096
    Location:40299
    Ndr; Ndr family
  14. NM_001354565.1NP_001341494.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  15. NM_001354566.1NP_001341495.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  16. NM_001354567.2NP_001341496.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  17. NM_001354568.1NP_001341497.1  protein NDRG2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9564.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  18. NM_001354569.1NP_001341498.1  protein NDRG2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9564.1
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  19. NM_001354570.1NP_001341499.1  protein NDRG2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS9565.1
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  20. NM_016250.3NP_057334.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_057334.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 encode the same isoform (b).
    Source sequence(s)
    AF304051, AL136574
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000344620.3, ENST00000350792.7
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  21. NM_201535.2NP_963293.1  protein NDRG2 isoform a

    See identical proteins and their annotated locations for NP_963293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 4, 6, 7 and 15 encode the same isoform (a).
    Source sequence(s)
    AF304051, AL136574
    Consensus CDS
    CCDS9565.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000298687.5, ENST00000298687.9
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  22. NM_201536.2NP_963294.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_963294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 encode the same isoform (b).
    Source sequence(s)
    AF304051, AL136574, CB153966
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000353649.3, ENST00000360463.7
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  23. NM_201537.1NP_963831.1  protein NDRG2 isoform a

    See identical proteins and their annotated locations for NP_963831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 7 and 15 encode the same isoform (a).
    Source sequence(s)
    AF159092, AF304051, AL136574, CB153966
    Consensus CDS
    CCDS9565.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380956.1, ENST00000397858.5
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  24. NM_201538.1NP_963832.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_963832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 encode the same isoform (b).
    Source sequence(s)
    AF159092, AF304051, AK057847, BX248031
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000452006.1, ENST00000554143.5
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family
  25. NM_201539.1NP_963833.1  protein NDRG2 isoform a

    See identical proteins and their annotated locations for NP_963833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 7 and 15 encode the same isoform (a).
    Source sequence(s)
    AF159092, AF304051, AK057847, AL136574
    Consensus CDS
    CCDS9565.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380949.2, ENST00000397851.6
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  26. NM_201540.1NP_963834.1  protein NDRG2 isoform a

    See identical proteins and their annotated locations for NP_963834.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 4, 6, 7 and 15 encode the same isoform (a).
    Source sequence(s)
    AF159092, AF304051, AK057847, BI759006, BX248031
    Consensus CDS
    CCDS9565.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380951.3, ENST00000397853.7
    Conserved Domains (1) summary
    pfam03096
    Location:40318
    Ndr; Ndr family
  27. NM_201541.1NP_963835.1  protein NDRG2 isoform b

    See identical proteins and their annotated locations for NP_963835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter N-terminus, compared to isoform a. Variants 2, 3, 5, 8, 11, and 12 encode the same isoform (b).
    Source sequence(s)
    AK057847, BF341160, BM810623, BX248031
    Consensus CDS
    CCDS9564.1
    UniProtKB/Swiss-Prot
    Q9UN36
    Related
    ENSP00000380954.4, ENST00000397856.7
    Conserved Domains (1) summary
    pfam03096
    Location:26304
    Ndr; Ndr family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21016763..21070872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center