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GTF2F2 general transcription factor IIF subunit 2 [ Homo sapiens (human) ]

Gene ID: 2963, updated on 5-Aug-2018

Summary

Official Symbol
GTF2F2provided by HGNC
Official Full Name
general transcription factor IIF subunit 2provided by HGNC
Primary source
HGNC:HGNC:4653
See related
Ensembl:ENSG00000188342 MIM:189969; Vega:OTTHUMG00000016849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTF4; RAP30; TF2F2; TFIIF
Expression
Ubiquitous expression in skin (RPKM 5.5), adrenal (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See GTF2F2 in Genome Data Viewer
Location:
13q14.12-q14.13
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (45119830..45284105)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45694631..45858240)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 3 Neighboring gene uncharacterized LOC101929259 Neighboring gene RNA, 7SK small nuclear pseudogene 4 Neighboring gene RNA, U6 small nuclear 69, pseudogene Neighboring gene potassium channel tetramerization domain containing 4 Neighboring gene uncharacterized LOC105370190 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIF, during Tat-mediated transactivation of the HIV-1 LTR PubMed
tat TFIIF synergizes with HIV-1 Tat and the cellular co-activator Tat-SF1 during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat directly interacts with the RAP30 subunit of TFIIF as demonstrated by Tat-affinity column purification PubMed
tat TFIIF is required for both basal and HIV-1 Tat-activated transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general transcription factor IIF subunit 2
Names
ATP-dependent helicase GTF2F2
TFIIF-beta
general transcription factor IIF 30 kDa subunit
general transcription factor IIF, polypeptide 2, 30kDa
transcription initiation factor IIF subunit beta
transcription initiation factor RAP30
NP_004119.1
XP_011533354.1
XP_011533355.1
XP_016876039.1
XP_016876040.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004128.2NP_004119.1  general transcription factor IIF subunit 2

    See identical proteins and their annotated locations for NP_004119.1

    Status: VALIDATED

    Source sequence(s)
    AK291545, BC001771, CA429230, CB124466, DB252856
    Consensus CDS
    CCDS9395.1
    UniProtKB/Swiss-Prot
    P13984
    UniProtKB/TrEMBL
    A0A024RDU9
    Related
    ENSP00000340823.6, OTTHUMP00000018348, ENST00000340473.7, OTTHUMT00000044767
    Conserved Domains (1) summary
    pfam02270
    Location:13236
    TFIIF_beta; Transcription initiation factor IIF, beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    45119830..45284105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020551.1XP_016876040.1  general transcription factor IIF subunit 2 isoform X3

  2. XM_011535052.3XP_011533354.1  general transcription factor IIF subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam02270
    Location:13262
    TFIIF_beta; Transcription initiation factor IIF, beta subunit
  3. XM_011535053.3XP_011533355.1  general transcription factor IIF subunit 2 isoform X4

    Conserved Domains (1) summary
    cd07980
    Location:5103
    TFIIF_beta; Transcription initiation factor IIF, beta subunit
  4. XM_017020550.2XP_016876039.1  general transcription factor IIF subunit 2 isoform X2

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