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Bpifb2 BPI fold containing family B, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296290, updated on 17-Aug-2024

Summary

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Official Symbol
Bpifb2provided by RGD
Official Full Name
BPI fold containing family B, member 2provided by RGD
Primary source
RGD:1310866
See related
EnsemblRapid:ENSRNOG00000012197 AllianceGenome:RGD:1310866
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bpil1; Lplunc2
Summary
Predicted to enable lipid binding activity. Predicted to be located in extracellular region. Orthologous to human BPIFB2 (BPI fold containing family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 2.2) See more
Orthologs
human mouse all
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Genomic context

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See Bpifb2 in Genome Data Viewer
Location:
3q41
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162818223..162837219)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142356990..142377053)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149358881..149377867)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486189 Neighboring gene EF-hand calcium binding domain 8 Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B, member 6 Neighboring gene BPI fold containing family B, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Bingle CD, et al. Biochem Soc Trans, 2011 Aug. PMID 21787333, Free PMC Article
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BPI fold-containing family B member 2
Names
bactericidal/permeability-increasing protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106531.1 → NP_001100001.1  BPI fold-containing family B member 2 precursor

    See identical proteins and their annotated locations for NP_001100001.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474050
    UniProtKB/TrEMBL
    A6KHW8, D4A5H4
    Related
    ENSRNOP00000016431.7, ENSRNOT00000016431.7
    Conserved Domains (2) summary
    pfam01273
    Location:33 → 184
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    cl00188
    Location:255 → 456
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    162818223..162837219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104607.2 → XP_038960535.1  BPI fold-containing family B member 2 isoform X1

    UniProtKB/TrEMBL
    D4A5H4
    Conserved Domains (2) summary
    pfam01273
    Location:60 → 211
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain
    cl00188
    Location:282 → 483
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
Nucleotide Protein Strain
Heading Accession and Version

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