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BPIFB2 BPI fold containing family B member 2 [ Homo sapiens (human) ]

Gene ID: 80341, updated on 5-Aug-2022

Summary

Official Symbol
BPIFB2provided by HGNC
Official Full Name
BPI fold containing family B member 2provided by HGNC
Primary source
HGNC:HGNC:16177
See related
Ensembl:ENSG00000078898 MIM:614108; AllianceGenome:HGNC:16177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RYSR; BPIL1; LPLUNC2; C20orf184; dJ726C3.2
Summary
This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]
Expression
Biased expression in salivary gland (RPKM 49.9) and esophagus (RPKM 45.9) See more
Orthologs
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Genomic context

See BPIFB2 in Genome Data Viewer
Location:
20q11.21
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33007704..33023703)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34734395..34750394)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31595510..31611509)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2101 Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B member 6 Neighboring gene pseudouridine 5'-phosphatase pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BPI fold-containing family B member 2
Names
BPI-like 1
bactericidal/permeability-increasing protein-like 1
long palate, lung and nasal epithelium carcinoma-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016714.1 RefSeqGene

    Range
    5104..21103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025227.3NP_079503.1  BPI fold-containing family B member 2 precursor

    See identical proteins and their annotated locations for NP_079503.1

    Status: REVIEWED

    Source sequence(s)
    AK027068, BC034415
    Consensus CDS
    CCDS13210.1
    UniProtKB/Swiss-Prot
    Q8N4F0, Q8NFQ7
    Related
    ENSP00000170150.3, ENST00000170150.4
    Conserved Domains (2) summary
    cd00026
    Location:254455
    BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    pfam01273
    Location:33184
    LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33007704..33023703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34734395..34750394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)