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GTF2F1 general transcription factor IIF subunit 1 [ Homo sapiens (human) ]

Gene ID: 2962, updated on 5-Jul-2020

Summary

Official Symbol
GTF2F1provided by HGNC
Official Full Name
general transcription factor IIF subunit 1provided by HGNC
Primary source
HGNC:HGNC:4652
See related
Ensembl:ENSG00000125651 MIM:189968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTF4; RAP74; TF2F1; TFIIF
Expression
Ubiquitous expression in ovary (RPKM 36.8), testis (RPKM 30.9) and 25 other tissues See more
Orthologs

Genomic context

See GTF2F1 in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6379569..6393186, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6379580..6393291, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene microRNA 6885 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIF, polypeptide 1 (GTF2F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Tat tat HIV-1 Tat inhibits the binding of RAP74 amino acids 436-517 to FCP1 PubMed
tat HIV-1 Tat stimulates the phosphorylation of TFIIF subunit RAP74 by TAFII250 during Tat-mediated transcription of the HIV-1 LTR promoter PubMed
tat TFIIF is required for both basal and HIV-1 Tat-activated transcription PubMed
tat TFIIF synergizes with HIV-1 Tat and the cellular co-activator Tat-SF1 during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIF, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
TFIIF-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
RNA metabolic process TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription elongation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
general transcription factor IIF subunit 1
Names
TFIIF-alpha
general transcription factor IIF 74 kDa subunit
general transcription factor IIF, polypeptide 1, 74kDa
transcription initiation factor IIF subunit alpha
transcription initiation factor RAP74

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002096.3NP_002087.2  general transcription factor IIF subunit 1

    See identical proteins and their annotated locations for NP_002087.2

    Status: VALIDATED

    Source sequence(s)
    BC013007, X64002, X64037
    Consensus CDS
    CCDS12165.1
    UniProtKB/Swiss-Prot
    P35269
    Related
    ENSP00000377969.3, ENST00000394456.10
    Conserved Domains (1) summary
    pfam05793
    Location:2517
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6379569..6393186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451475.1XP_024307243.1  general transcription factor IIF subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam05793
    Location:2542
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
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