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GTF2E2 general transcription factor IIE subunit 2 [ Homo sapiens (human) ]

Gene ID: 2961, updated on 24-Nov-2020

Summary

Official Symbol
GTF2E2provided by HGNC
Official Full Name
general transcription factor IIE subunit 2provided by HGNC
Primary source
HGNC:HGNC:4651
See related
Ensembl:ENSG00000197265 MIM:189964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FE; TTD6; TF2E2; TFIIE-B
Summary
The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See GTF2E2 in Genome Data Viewer
Location:
8p12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30578318..30658241, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30436031..30515738, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene Sharpr-MPRA regulatory region 2547 Neighboring gene uncharacterized LOC112268024 Neighboring gene RNA, U5A small nuclear 3, pseudogene Neighboring gene small integral membrane protein 18 Neighboring gene glutathione-disulfide reductase Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available
Trichothiodystrophy 6, nonphotosensitive
MedGen: C4310785 OMIM: 616943 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIE, polypeptide 2, beta 34kDa (GTF2E2; TFIIE-B) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIE, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor IIE subunit beta
Names
TFIIE beta subunit
TFIIE-beta
general transcription factor IIE, polypeptide 2, beta 34kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052833.1 RefSeqGene

    Range
    5006..84924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348353.1NP_001335282.1  transcription initiation factor IIE subunit beta isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102945, AC103959
    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2
  2. NM_002095.6NP_002086.1  transcription initiation factor IIE subunit beta isoform 1

    See identical proteins and their annotated locations for NP_002086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA483281, BC030572, BX421791
    Consensus CDS
    CCDS6078.1
    UniProtKB/Swiss-Prot
    P29084
    Related
    ENSP00000348168.4, ENST00000355904.9
    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30578318..30658241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013364.1XP_016868853.1  transcription initiation factor IIE subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P29084
    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2
  2. XM_017013363.1XP_016868852.1  transcription initiation factor IIE subunit beta isoform X1

    UniProtKB/Swiss-Prot
    P29084
    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2
  3. XM_024447138.1XP_024302906.1  transcription initiation factor IIE subunit beta isoform X1

    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2
  4. XM_011544509.2XP_011542811.1  transcription initiation factor IIE subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011542811.1

    Conserved Domains (2) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    pfam18121
    Location:146204
    TFA2_Winged_2; TFA2 Winged helix domain 2
  5. XM_011544510.1XP_011542812.1  transcription initiation factor IIE subunit beta isoform X3

    Related
    ENSP00000429921.1, ENST00000518599.5
    Conserved Domains (1) summary
    cd07977
    Location:68146
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
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