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GTF2A1 general transcription factor IIA subunit 1 [ Homo sapiens (human) ]

Gene ID: 2957, updated on 3-Jan-2019

Summary

Official Symbol
GTF2A1provided by HGNC
Official Full Name
general transcription factor IIA subunit 1provided by HGNC
Primary source
HGNC:HGNC:4646
See related
Ensembl:ENSG00000165417 MIM:600520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF2A1; TFIIA; TFIIAL; TFIIA-42
Summary
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in thyroid (RPKM 15.3), testis (RPKM 12.9) and 25 other tissues See more
Orthologs

Genomic context

See GTF2A1 in Genome Data Viewer
Location:
14q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (81175452..81221231, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (81641796..81687575, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thyroid stimulating hormone receptor Neighboring gene NMNAT1 pseudogene 1 Neighboring gene uncharacterized LOC101928462 Neighboring gene uncharacterized LOC105370594 Neighboring gene GTF2A1 intron CAGE-defined high expression enhancer Neighboring gene uncharacterized LOC101928504 Neighboring gene small nucleolar RNA, H/ACA box 79 Neighboring gene dynein light chain LC8-type 1 pseudogene 1 Neighboring gene uracil-DNA glycosylase pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIA, 1, 19/37kDa (GTF2A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21525, MGC129969, MGC129970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
TBP-class protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor IIA subunit 1
Names
TFIIA alpha, p55, isoform 1
TFIIA alpha/beta subunits
general transcription factor IIA 1
general transcription factor IIA, 1, 19/37kDa
glucose regulated protein, 58kD pseudogene
transcription initiation factor TFIIA 42 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278940.1NP_001265869.1  transcription initiation factor IIA subunit 1 isoform 3

    See identical proteins and their annotated locations for NP_001265869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL136040, BC050703, BC107156
    UniProtKB/Swiss-Prot
    P52655
    Conserved Domains (1) summary
    pfam03153
    Location:142326
    TFIIA; Transcription factor IIA, alpha/beta subunit
  2. NM_015859.4NP_056943.1  transcription initiation factor IIA subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_056943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL136040, BC050703, D14887
    Consensus CDS
    CCDS9873.1
    UniProtKB/Swiss-Prot
    P52655
    Related
    ENSP00000452454.1, ENST00000553612.5
    Conserved Domains (1) summary
    pfam03153
    Location:13376
    TFIIA; Transcription factor IIA, alpha/beta subunit
  3. NM_201595.2NP_963889.1  transcription initiation factor IIA subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_963889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL136040, D14886
    Consensus CDS
    CCDS9874.1
    UniProtKB/Swiss-Prot
    P52655
    Related
    ENSP00000409492.2, ENST00000434192.2
    Conserved Domains (2) summary
    pfam03153
    Location:153337
    TFIIA; Transcription factor IIA, alpha/beta subunit
    cl21683
    Location:221
    TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    81175452..81221231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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