GSTP1 glutathione S-transferase pi 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTP1provided by HGNC
Official Full Name: glutathione S-transferase pi 1provided by HGNC
Primary source: HGNC:HGNC:4638
See related: Ensembl:ENSG00000084207 MIM:134660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in esophagus (RPKM 400.7), thyroid (RPKM 188.1) and 24 other tissues See more
Orthologs: all

Genomic context

Location:: 11q13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	11	NC_000011.10 (67583812..67586653)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (67351066..67354125)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSTP1 AG/GG genotype had significantly a lower rate of major molecular response achievement *(AG/GG) was associated with chronic myeloid leukemia risk.
Title: Influence of glutathione S-transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment response.
We establish the Malian frequencies of the GSTM1, GSTT1, and GSTP1 c. 313A > G (rs1695) polymorphisms. The frequencies of GSTM1-null and GSTT1-null genotypes were respectively 24.3 and 41.3%. The observed genotype frequencies for GSTP1 were 25.73% homozygous wild-type AA, 49.03% heterozygous AG and 25.24% homozygous mutant GG. The frequency of GSTP1-A allele was 50.24% versus 49.76% for the GSTP1-G allele.
Title: Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population.
This meta-analysis indicates that the individual and combined effects of GSTM1, GSTT1 and GSTP1 polymorphisms may be not associated with increased BC risk.
Title: Individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on breast cancer risk: A meta-analysis and re-analysis of systematic meta-analyses.
Glutathione S-transferase genetic polymorphisms affect the risk of systemic sclerosis in the Polish population.
Title: Analysis of genetic polymorphisms of glutathione S-transferase (GSTP1, GSTM1, and GSTT1) in Polish patients with systemic sclerosis.
GSTP1, HO-1, and SOD3 genetic polymorphisms may play a significant role in the development of COPD susceptibility, but are not associated with the different stages of COPD.
Title: Association among genetic polymorphisms of GSTP1, HO-1, and SOD-3 and chronic obstructive pulmonary disease susceptibility.
GSTP1 exon 6 polymorphism genotype was associated with an increase in the risk of hepatocellular carcinoma in male patients and that it tended to be related to cancer differentiation.
Title: Glutathione S-Transferase P1 Polymorphism on Exon 6 and Risk of Hepatocellular Carcinoma in Thai Male Patients.
GSTP1 gene deletion and Single Nucleotide Polymorphism is associated with Colorectal Cancer Development.
Title: Deletion and Single Nucleotide Polymorphisms in Common Glutathione-S Transferases Contribute to Colorectal Cancer Development.
Individuals possessing the GSTM1del, GSTT1del, GSTP1 105I/V(+313A/G), CAT-21A/T, SOD2 + 47C/T and GPx1 + 599C/T are at very high risk of developing type 2 diabetes mellitus.
Title: Interaction of antioxidant gene variants and susceptibility to type 2 diabetes mellitus.
Thus, in turn, GST P1-1 overexpression and Pt-induced subunit cross-linking could modulate JNK apoptotic signaling, further confirming the role of GST P1-1 as an antiapoptotic protein.
Title: A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.
The GSTP1 rs1695 gene polymorphism can play a protective role in the development of toxic liver damage in petrochemical workers.
Title: Polymorphism of Glutathione S-transferase Genes and the Risk of Toxic Liver Damage in Petrochemical Workers.

Submit: New GeneRIF Correction See all GeneRIFs (904)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47100 (e-PCR)
- UniSTS:73781

GSTP1 (e-PCR)
- UniSTS:44904

G60258 (e-PCR)
- UniSTS:137364

GDB:270066 (e-PCR)
- UniSTS:156344

MARC_5389-5390:996690338:1 (e-PCR)
- UniSTS:269499

D11S4609 (e-PCR)
- UniSTS:11198

Homology

Homologs of the GSTP1 gene: The GSTP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 101 organisms have orthologs with human gene GSTP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
JUN kinase binding	ISS Inferred from Sequence or Structural Similarity more info
S-nitrosoglutathione binding	IDA Inferred from Direct Assay more info	PubMed
dinitrosyl-iron complex binding	IDA Inferred from Direct Assay more info	PubMed
drug binding	IEA Inferred from Electronic Annotation more info
fatty acid binding	IPI Inferred from Physical Interaction more info	PubMed
glutathione binding	IEA Inferred from Electronic Annotation more info
glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
nitric oxide binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
animal organ regeneration	IEA Inferred from Electronic Annotation more info
cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
cellular response to cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
cellular response to oxidative stress	TAS Traceable Author Statement more info
central nervous system development	TAS Traceable Author Statement more info	PubMed
common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
glutathione derivative biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
glutathione derivative biosynthetic process	TAS Traceable Author Statement more info
glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
hepoxilin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
negative regulation of acute inflammatory response	NAS Non-traceable Author Statement more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell chemotaxis	IEA Inferred from Electronic Annotation more info
negative regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor-mediated signaling pathway	IC Inferred by Curator more info	PubMed
negative regulation of vascular smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
neutrophil degranulation	TAS Traceable Author Statement more info
nitric oxide storage	NAS Non-traceable Author Statement more info	PubMed
oligodendrocyte development	IEA Inferred from Electronic Annotation more info
positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
response to L-ascorbic acid	IEA Inferred from Electronic Annotation more info
response to amino acid	IEA Inferred from Electronic Annotation more info
response to estradiol	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
TRAF2-GSTP1 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	HDA more info	PubMed
ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
mitochondrion	IDA Inferred from Direct Assay more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
secretory granule lumen	TAS Traceable Author Statement more info
vesicle	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase P

Names: GST class-pi; GSTP1-1; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III

NP_000843.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012075.1 RefSeqGene

Range

5001..8059

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_723

mRNA and Protein(s)

NM_000852.4 → NP_000843.1 glutathione S-transferase P

See identical proteins and their annotated locations for NP_000843.1

Status: REVIEWED

Source sequence(s)

BC010915, X15480

Consensus CDS

CCDS41679.1

UniProtKB/Swiss-Prot

P09211

UniProtKB/TrEMBL

V9HWE9

Related

ENSP00000381607.3, ENST00000398606.10

Conserved Domains (2) summary

cd03210
Location:84 → 210

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...