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GSTP1 glutathione S-transferase pi 1 [ Homo sapiens (human) ]

Gene ID: 2950, updated on 9-Dec-2018

Summary

Official Symbol
GSTP1provided by HGNC
Official Full Name
glutathione S-transferase pi 1provided by HGNC
Primary source
HGNC:HGNC:4638
See related
Ensembl:ENSG00000084207 MIM:134660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
Summary
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 400.7), thyroid (RPKM 188.1) and 24 other tissues See more
Orthologs

Genomic context

See GSTP1 in Genome Data Viewer
Location:
11q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (67583595..67586653)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67351066..67354125)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 associated protein 2 Neighboring gene calcium binding protein 2 Neighboring gene chromosome 11 open reading frame 72 (putative) Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
S-nitrosoglutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
dinitrosyl-iron complex binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
glutathione binding IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
nitric oxide binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of acute inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
negative regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nitric oxide storage NAS
Non-traceable Author Statement
more info
PubMed 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
response to L-ascorbic acid IEA
Inferred from Electronic Annotation
more info
 
response to amino acid IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
TRAF2-GSTP1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase P
Names
GST class-pi
GSTP1-1
deafness, X-linked 7
epididymis secretory protein Li 22
fatty acid ethyl ester synthase III
NP_000843.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012075.1 RefSeqGene

    Range
    5001..8059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_723

mRNA and Protein(s)

  1. NM_000852.3NP_000843.1  glutathione S-transferase P

    See identical proteins and their annotated locations for NP_000843.1

    Status: REVIEWED

    Source sequence(s)
    BC010915, CA946272, X15480
    Consensus CDS
    CCDS41679.1
    UniProtKB/Swiss-Prot
    P09211
    UniProtKB/TrEMBL
    V9HWE9
    Related
    ENSP00000381607.3, ENST00000398606.8
    Conserved Domains (2) summary
    cd03210
    Location:84210
    GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
    cd03076
    Location:376
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    67583595..67586653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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