GSTP1 glutathione S-transferase pi 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTP1provided by HGNC
Official Full Name: glutathione S-transferase pi 1provided by HGNC
Primary source: HGNC:HGNC:4638
See related: Ensembl:ENSG00000084207 MIM:134660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in esophagus (RPKM 400.7), thyroid (RPKM 188.1) and 24 other tissues See more
Orthologs: all

Genomic context

Location:: 11q13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (67583595..67586653)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (67351066..67354125)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

GSTP1 inactivating polymorphism is associated with acute myeloid leukemia.
Title: Association of GSTP1 inactivating polymorphism with acute myeloid leukemia and its specific chromosomal abnormalities.
the null GSTM1 and the GG genotype of GSTP1 IIe105Val were associated with improved treatment response to cisplatin-based chemotherapy (GSTT1 present/null: OR=1.328; 95% CI, 1.074-1.643) (GSTP1 GG + AG vs. AA: OR=0.596; 95% CI, 0.468-0.759).
Title: Glutathione S-Transferase Gene Polymorphisms are Associated with an Improved Treatment Response to Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer (NSCLC): A Meta-Analysis.
data suggest that GSTP1 expression is not associated with bladder cancer (BC) development, limiting its use as a biomarker for BC management in Morocco. Moreover, difference in GSTP1 expression among BC cases is not due to GSTP1 promoter methylation.
Title: Evaluation of glutathione S-transferase pi 1 expression and gene promoter methylation in Moroccan patients with urothelial bladder cancer.
Methylation GSTP1 is associated with Breast Cancer.
Title: Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast Cancer
Prenatal fine particulate exposure in late pregnancy was associated with impaired childhood lung function and hypermethylation of GSTP1 in nasal epithelium.
Title: Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects.
The study revealed association of GSTP1 I105V with Infectious Endocarditis, but the disease proved unrelated to GSTP1 A114V polymorphism.
Title: [Polymorphisms of genesencoding enzymes of the xenobiotic detoxification system and the risk of infectious endocarditis].
The results of this meta-analysis suggest that GSTP1 hypermethylation induces the inactivation of GSTP1 gene, plays an important role in hepatocarcinogenesis, and is associated with an increased risk of HCC.
Title: Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: A meta-analysis.
The expression levels of LRP and GSTP1 in primary epithelial ovarian cancer were the highest, followed by borderline adenoma tissues, and lowest levels in benign tumor tissues. The difference between resistant gene negative-expression and positive-expression of chemotherapy efficiency, disease free survival time, and recurrence time were statistically significant.
Title: Expression of resistance gene and prognosis of chemotherapy in primary epithelial ovarian cancer.
polymorphisms do not have any large effect on risk of cutaneous malignant melanoma [meta-analysis]
Title: GSTP1 does not modify MC1R effects on melanoma risk.
There is a multifarious interaction between the DNA repair gene ERCC5 SNPs (rs2094258 and rs873601) and the metabolic gene GSTP1 rs1695, which may form the basis for various inter-individual susceptibilities to atrophic gastritis in Chinese population.
Title: Impact of SNP-SNP interactions of DNA repair gene <i>ERCC5</i> and metabolic gene <i>GSTP1</i> on gastric cancer/atrophic gastritis risk in a Chinese population.

Submit: New GeneRIF Correction See all GeneRIFs (858)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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4-hydroxy-2-nonenal detoxification, organism-specific biosystem (from BIOCYC)
4-hydroxy-2-nonenal detoxification, organism-specific biosystem
4-hydroxy-2-nonenal detoxification
Arachidonate Epoxygenase / Epoxide Hydrolase, organism-specific biosystem (from WikiPathways)
Arachidonate Epoxygenase / Epoxide Hydrolase, organism-specific biosystemThe cytochrome P450-dependent formation of polyunsaturated fatty acid epoxides is an important biochemical pathway creating mediators of inflammation and blood pressure regulation. Once formed these...
Biological oxidations, organism-specific biosystem (from REACTOME)
Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
Cellular responses to stress, organism-specific biosystem (from REACTOME)
Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
Chemical carcinogenesis, organism-specific biosystem (from KEGG)
Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Chemical carcinogenesis, conserved biosystem (from KEGG)
Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
Detoxification of Reactive Oxygen Species, organism-specific biosystemReactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewe...
Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
Drug metabolism - cytochrome P450, organism-specific biosystem
Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
Drug metabolism - cytochrome P450, conserved biosystem
Drug metabolism - cytochrome P450
Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
Glutathione conjugation, organism-specific biosystem (from REACTOME)
Glutathione conjugation, organism-specific biosystemGlutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are e...
Glutathione metabolism, organism-specific biosystem (from KEGG)
Glutathione metabolism, organism-specific biosystem
Glutathione metabolism
Glutathione metabolism, conserved biosystem (from KEGG)
Glutathione metabolism, conserved biosystem
Glutathione metabolism
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Metabolism of xenobiotics by cytochrome P450
Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, conserved biosystem
Metabolism of xenobiotics by cytochrome P450
Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
Metapathway biotransformation, organism-specific biosystem
Metapathway biotransformation
NRF2 pathway, organism-specific biosystem (from WikiPathways)
NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phase II conjugation, organism-specific biosystem (from REACTOME)
Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystem (from WikiPathways)
Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, organism-specific biosystemPhotodynamic therapy may induce an antioxidant response mediated by NFE2L2.
Platinum drug resistance, organism-specific biosystem (from KEGG)
Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
Platinum drug resistance, conserved biosystem (from KEGG)
Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
glutathione-mediated detoxification, organism-specific biosystem (from BIOCYC)
glutathione-mediated detoxification, organism-specific biosystemPlease note: This is a general detoxification pathway, where the first step can be catalyzed by many different enzymes, collectively known as glutathione transferases, or GSTs. In the first reaction,...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47100 (e-PCR)
- UniSTS:73781

GSTP1 (e-PCR)
- UniSTS:44904

G60258 (e-PCR)
- UniSTS:137364

GDB:270066 (e-PCR)
- UniSTS:156344

MARC_5389-5390:996690338:1 (e-PCR)
- UniSTS:269499

D11S4609 (e-PCR)
- UniSTS:11198

Homology

Homologs of the GSTP1 gene: The GSTP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 83 organisms have orthologs with human gene GSTP1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
JUN kinase binding	ISS Inferred from Sequence or Structural Similarity more info
S-nitrosoglutathione binding	IDA Inferred from Direct Assay more info	PubMed
dinitrosyl-iron complex binding	IDA Inferred from Direct Assay more info	PubMed
drug binding	IEA Inferred from Electronic Annotation more info
glutathione binding	IEA Inferred from Electronic Annotation more info
glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
glutathione transferase activity	TAS Traceable Author Statement more info
kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
nitric oxide binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
animal organ regeneration	IEA Inferred from Electronic Annotation more info
cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
cellular response to cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
central nervous system development	TAS Traceable Author Statement more info	PubMed
common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
glutathione derivative biosynthetic process	TAS Traceable Author Statement more info
glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
negative regulation of acute inflammatory response	NAS Non-traceable Author Statement more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of leukocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell chemotaxis	IEA Inferred from Electronic Annotation more info
negative regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor-mediated signaling pathway	IC Inferred by Curator more info	PubMed
negative regulation of vascular smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
neutrophil degranulation	TAS Traceable Author Statement more info
nitric oxide storage	NAS Non-traceable Author Statement more info	PubMed
oligodendrocyte development	IEA Inferred from Electronic Annotation more info
positive regulation of superoxide anion generation	ISS Inferred from Sequence or Structural Similarity more info
regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
response to L-ascorbic acid	IEA Inferred from Electronic Annotation more info
response to amino acid	IEA Inferred from Electronic Annotation more info
response to estradiol	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
TRAF2-GSTP1 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
extracellular exosome	HDA more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	HDA more info	PubMed
ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
mitochondrion	IDA Inferred from Direct Assay more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
secretory granule lumen	TAS Traceable Author Statement more info
vesicle	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase P

Names: GST class-pi; GSTP1-1; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III

NP_000843.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012075.1 RefSeqGene

Range

5001..8059

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_723

mRNA and Protein(s)

NM_000852.3 → NP_000843.1 glutathione S-transferase P

See identical proteins and their annotated locations for NP_000843.1

Status: REVIEWED

Source sequence(s)

BC010915, CA946272, X15480

Consensus CDS

CCDS41679.1

UniProtKB/Swiss-Prot

P09211

UniProtKB/TrEMBL

V9HWE9

Related

ENSP00000381607.3, ENST00000398606.8

Conserved Domains (2) summary

cd03210
Location:84 → 210

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...