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Wdr70 WD repeat domain 70 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294783, updated on 17-Aug-2024

Summary

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Official Symbol
Wdr70provided by RGD
Official Full Name
WD repeat domain 70provided by RGD
Primary source
RGD:1309487
See related
EnsemblRapid:ENSRNOG00000013336 AllianceGenome:RGD:1309487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309487
Summary
Predicted to enable enzyme binding activity. Predicted to be involved in regulation of DNA double-strand break processing and regulation of histone H2B conserved C-terminal lysine ubiquitination. Predicted to be active in nucleus and site of double-strand break. Orthologous to human WDR70 (WD repeat domain 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 85.2), Brain (RPKM 67.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q16
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (58678651..58918523, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (56951345..57191244, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (56944462..57196522, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485851 Neighboring gene U2 spliceosomal RNA Neighboring gene glial cell derived neurotrophic factor Neighboring gene phospholipase D family, member 6, pseudogene 1 Neighboring gene uncharacterized LOC120100734 Neighboring gene nucleoporin 155 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 29 Neighboring gene ciliogenesis and planar polarity effector complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109151

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013909.1 → NP_001013931.1  WD repeat-containing protein 70

    See identical proteins and their annotated locations for NP_001013931.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089903
    UniProtKB/Swiss-Prot
    Q5EB92
    UniProtKB/TrEMBL
    A6KGH3
    Related
    ENSRNOP00000056890.2, ENSRNOT00000060146.6
    Conserved Domains (2) summary
    sd00039
    Location:186 → 228
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:178 → 499
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    58678651..58918523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101944.2 → XP_038957872.1  WD repeat-containing protein 70 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:20 → 68
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:17 → 285
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_063281520.1 → XP_063137590.1  WD repeat-containing protein 70 isoform X1

  3. XM_039101946.2 → XP_038957874.1  WD repeat-containing protein 70 isoform X2

    UniProtKB/TrEMBL
    A6KGH4
    Related
    ENSRNOP00000104956.1, ENSRNOT00000128016.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5EB92.1 GenPept UniProtKB/Swiss-Prot:Q5EB92

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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