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GSTM3 glutathione S-transferase mu 3 [ Homo sapiens (human) ]

Gene ID: 2947, updated on 13-Jan-2019

Summary

Official Symbol
GSTM3provided by HGNC
Official Full Name
glutathione S-transferase mu 3provided by HGNC
Primary source
HGNC:HGNC:4635
See related
Ensembl:ENSG00000134202 MIM:138390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST5; GSTB; GTM3; GSTM3-3
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Expression
Broad expression in testis (RPKM 82.2), kidney (RPKM 34.8) and 16 other tissues See more
Orthologs

Genomic context

See GSTM3 in Genome Data Viewer
Location:
1p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (109733932..109741038, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110276554..110283660, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 5 Neighboring gene EPS8 like 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3310, MGC3704

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular detoxification of nitrogen compound IDA
Inferred from Direct Assay
more info
PubMed 
establishment of blood-nerve barrier TAS
Traceable Author Statement
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
nitrobenzene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
sperm fibrous sheath IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione S-transferase Mu 3
Names
GST class-mu 3
S-(hydroxyalkyl)glutathione lyase M3
brain GST
brain type mu-glutathione S-transferase
epididymis secretory sperm binding protein
glutathione S-alkyltransferase M3
glutathione S-aralkyltransferase M3
glutathione S-aryltransferase M3
glutathione S-transferase M3 (brain)
glutathione S-transferase mu 3 (brain)
glutathione S-transferase, Mu-3
hGSTM3-3
NP_000840.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000849.4NP_000840.2  glutathione S-transferase Mu 3

    See identical proteins and their annotated locations for NP_000840.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL158847, BC008790, BC030253
    Consensus CDS
    CCDS812.1
    UniProtKB/Swiss-Prot
    P21266
    UniProtKB/TrEMBL
    Q6FGJ9
    Related
    ENSP00000354357.2, ENST00000361066.6
    Conserved Domains (2) summary
    cd03209
    Location:96216
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:788
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RNA

  1. NR_024537.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and early stop codon. The predicted protein is not represented because the product is significantly truncated and the transcript is likely to be a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AK304300, AL158847, BC008790, BC030253

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    109733932..109741038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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