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GSTA4 glutathione S-transferase alpha 4 [ Homo sapiens (human) ]

Gene ID: 2941, updated on 12-Aug-2018

Summary

Official Symbol
GSTA4provided by HGNC
Official Full Name
glutathione S-transferase alpha 4provided by HGNC
Primary source
HGNC:HGNC:4629
See related
Ensembl:ENSG00000170899 MIM:605450; Vega:OTTHUMG00000014868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTA4; GSTA4-4
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 149.4), skin (RPKM 38.6) and 16 other tissues See more
Orthologs

Genomic context

See GSTA4 in Genome Data Viewer
Location:
6p12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (52977948..52995380, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52842746..52860178, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375091 Neighboring gene glutathione S-transferase alpha 3 Neighboring gene glutathione S-transferase alpha 9, pseudogene Neighboring gene RNA, 7SK small nuclear Neighboring gene intestinal cell kinase Neighboring gene F-box protein 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of glutathione S-transferase alpha 4 (GSTA4) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686D21185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutathione S-transferase A4
Names
GST class-alpha member 4
S-(hydroxyalkyl)glutathione lyase A4
glutathione S-alkyltransferase A4
glutathione S-aralkyltransferase A4
glutathione S-aryltransferase A4
glutathione S-transferase A4-4
glutathione transferase A4-4
NP_001503.1
XP_005249092.1
XP_011512836.1
XP_011512837.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001512.3NP_001503.1  glutathione S-transferase A4

    See identical proteins and their annotated locations for NP_001503.1

    Status: REVIEWED

    Source sequence(s)
    AA709059, AK315369, BC063439, DA521337
    Consensus CDS
    CCDS4948.1
    UniProtKB/Swiss-Prot
    O15217
    UniProtKB/TrEMBL
    A0A024RD58
    Related
    ENSP00000360002.4, OTTHUMP00000016624, ENST00000370963.8, OTTHUMT00000040944
    Conserved Domains (2) summary
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:482
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    52977948..52995380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249035.4XP_005249092.1  glutathione S-transferase A4 isoform X1

    See identical proteins and their annotated locations for XP_005249092.1

    UniProtKB/Swiss-Prot
    O15217
    UniProtKB/TrEMBL
    A0A024RD58
    Conserved Domains (2) summary
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:482
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_011514535.3XP_011512837.1  glutathione S-transferase A4 isoform X2

    See identical proteins and their annotated locations for XP_011512837.1

    Conserved Domains (2) summary
    cd03208
    Location:49183
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:1245
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. XM_011514534.3XP_011512836.1  glutathione S-transferase A4 isoform X2

    See identical proteins and their annotated locations for XP_011512836.1

    Conserved Domains (2) summary
    cd03208
    Location:49183
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:1245
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
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