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GSTA2 glutathione S-transferase alpha 2 [ Homo sapiens (human) ]

Gene ID: 2939, updated on 23-Nov-2021

Summary

Official Symbol
GSTA2provided by HGNC
Official Full Name
glutathione S-transferase alpha 2provided by HGNC
Primary source
HGNC:HGNC:4627
See related
Ensembl:ENSG00000244067 MIM:138360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST2; GTA2; GTH2; GSTA2-2
Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 492.6), kidney (RPKM 310.5) and 6 other tissues See more
Orthologs
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Genomic context

See GSTA2 in Genome Data Viewer
Location:
6p12.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52750087..52763475, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52614885..52628273, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SREK1IP1 pseudogene 2 Neighboring gene glutathione S-transferase alpha 8, pseudogene Neighboring gene glutathione S-transferase alpha 7, pseudogene Neighboring gene glutathione S-transferase alpha 12, pseudogene Neighboring gene glutathione S-transferase alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutathione S-transferase A2
Names
GST HA subunit 2
GST class-alpha member 2
GST-gamma
S-(hydroxyalkyl)glutathione lyase A2
glutathione S-alkyltransferase A2
glutathione S-aralkyltransferase A2
glutathione S-aryltransferase A2
liver GST2
testis tissue sperm-binding protein Li 59n
NP_000837.3
XP_011512834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029430.1 RefSeqGene

    Range
    5089..18477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000846.5NP_000837.3  glutathione S-transferase A2

    See identical proteins and their annotated locations for NP_000837.3

    Status: REVIEWED

    Source sequence(s)
    AK292602, AL109918, BC002895, BU685446
    Consensus CDS
    CCDS4944.1
    UniProtKB/Swiss-Prot
    P09210
    UniProtKB/TrEMBL
    A0A140VKE2, A8K987
    Related
    ENSP00000420168.1, ENST00000493422.3
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    52750087..52763475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514532.3XP_011512834.1  glutathione S-transferase A2 isoform X1

    See identical proteins and their annotated locations for XP_011512834.1

    UniProtKB/Swiss-Prot
    P09210
    UniProtKB/TrEMBL
    A0A140VKE2
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
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