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Map4k2 mitogen activated protein kinase kinase kinase kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293694, updated on 17-Aug-2024

Summary

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Official Symbol
Map4k2provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase kinase 2provided by RGD
Primary source
RGD:1308199
See related
EnsemblRapid:ENSRNOG00000021061 AllianceGenome:RGD:1308199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; protein phosphorylation; and vesicle targeting. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 158.7), Lung (RPKM 156.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213074360..213090042)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203645098..203660782)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221710622..221726274)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase gamma Neighboring gene uncharacterized LOC134483959 Neighboring gene menin 1 Neighboring gene uncharacterized LOC134483960 Neighboring gene U7 small nuclear RNA Neighboring gene splicing factor 1 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene uncharacterized LOC120097407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Ren M, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643544, Free PMC Article
  2. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Chadee DN, et al. Mol Cell Biol, 2002 Feb. PMID 11784851, Free PMC Article
  3. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. Zhong J, et al. J Biol Chem, 2007 Aug 17. PMID 17584736
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle targeting ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 2
NP_001402759.1
NP_001402760.1
XP_038964431.1
XP_038964433.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415830.1 → NP_001402759.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HZG5, A6HZG6
    Related
    ENSRNOP00000102460.1, ENSRNOT00000159644.1

  2. NM_001415831.1 → NP_001402760.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HZG6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213074360..213090042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108505.2 → XP_038964433.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    Conserved Domains (2) summary
    cd06613
    Location:16 → 272
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    cl02434
    Location:489 → 573
    CNH; CNH domain

  2. XM_039108503.2 → XP_038964431.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A6HZG6, D3ZXB1
    Related
    ENSRNOP00000059958.2, ENSRNOT00000064798.5
    Conserved Domains (2) summary
    smart00036
    Location:424 → 736
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:40 → 207
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106329.1: Suppressed sequence

    Description
    NM_001106329.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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