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Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 26412, updated on 22-May-2022

Summary

Official Symbol
Map4k2provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 2provided by MGI
Primary source
MGI:MGI:1346883
See related
Ensembl:ENSMUSG00000024948 AllianceGenome:MGI:1346883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCK; BL44; Rab8ip; AI385662
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi apparatus and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues See more
Orthologs
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Genomic context

See Map4k2 in Genome Data Viewer
Location:
19; 19 A
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6391023..6405649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6340990..6355619)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6341250..6353527)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase gamma (DMPK-like) Neighboring gene multiple endocrine neoplasia 1 Neighboring gene microRNA 6989 Neighboring gene U7 small nuclear RNA Neighboring gene predicted gene 14966 Neighboring gene splicing factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC143893, MGC143894

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle targeting IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 2
Names
MAPK/ERK kinase kinase kinase 2
MEK kinase kinase 2
MEKKK 2
RAB8 interacting protein
germinal center kinase
rab8-interacting protein
NP_001278716.1
NP_033032.1
XP_006531818.1
XP_006531819.1
XP_006531820.1
XP_006531823.1
XP_017173700.1
XP_017173701.1
XP_036017493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291787.1NP_001278716.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001278716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC127556, AK051036, BC034109, BY275230, BY753233
    UniProtKB/Swiss-Prot
    Q61161
    Conserved Domains (2) summary
    smart00036
    Location:400712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1183
    PKc_like; Protein Kinases, catalytic domain
  2. NM_009006.3NP_033032.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_033032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC127556, AK051036, BC034109, BY753233
    Consensus CDS
    CCDS29503.1
    UniProtKB/Swiss-Prot
    Q61161
    Related
    ENSMUSP00000025897.7, ENSMUST00000025897.13
    Conserved Domains (3) summary
    smart00036
    Location:489801
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16272
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RNA

  1. NR_117093.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains an intron and uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC127556, AK011708, AK051036, BC034109, BY753233

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6391023..6405649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531755.4XP_006531818.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531818.1

    Conserved Domains (2) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036161600.1XP_036017493.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X3

    Related
    ENSMUST00000133696.8
    Conserved Domains (2) summary
    smart00036
    Location:423735
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:39206
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017318211.3XP_017173700.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83
    Conserved Domains (2) summary
    smart00036
    Location:445757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:38228
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006531760.5XP_006531823.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X4

    See identical proteins and their annotated locations for XP_006531823.1

    Conserved Domains (2) summary
    smart00036
    Location:400712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1183
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017318212.2XP_017173701.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83
    Conserved Domains (2) summary
    smart00036
    Location:445757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:38228
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006531756.4XP_006531819.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531819.1

    Conserved Domains (2) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006531757.2XP_006531820.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531820.1

    Conserved Domains (2) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001782591.3 RNA Sequence

    Related
    ENSMUST00000124556.8