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Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 26412, updated on 12-Aug-2018

Summary

Official Symbol
Map4k2provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 2provided by MGI
Primary source
MGI:MGI:1346883
See related
Ensembl:ENSMUSG00000024948 Vega:OTTMUSG00000018616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCK; BL44; Rab8ip; AI385662
Expression
Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues See more
Orthologs

Genomic context

See Map4k2 in Genome Data Viewer
Location:
19; 19 A
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (6341117..6355619)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6341250..6353527)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase gamma (DMPK-like) Neighboring gene multiple endocrine neoplasia 1 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene splicing factor 1 Neighboring gene muscle glycogen phosphorylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from BioSystems

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

General gene information

Markers

Homology

Clone Names

  • MGC143893, MGC143894

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle targeting IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 2
Names
MAPK/ERK kinase kinase kinase 2
MEK kinase kinase 2
MEKKK 2
RAB8 interacting protein
germinal center kinase
rab8-interacting protein
NP_001278716.1
NP_033032.1
XP_006531818.1
XP_006531819.1
XP_006531820.1
XP_006531821.1
XP_006531823.1
XP_017173700.1
XP_017173701.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291787.1NP_001278716.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001278716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC127556, AK051036, BC034109, BY275230, BY753233
    UniProtKB/Swiss-Prot
    Q61161
    Conserved Domains (3) summary
    smart00036
    Location:400712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1183
    PKc_like; Protein Kinases, catalytic domain
  2. NM_009006.3NP_033032.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_033032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC127556, AK051036, BC034109, BY753233
    Consensus CDS
    CCDS29503.1
    UniProtKB/Swiss-Prot
    Q61161
    Related
    ENSMUSP00000025897.6, OTTMUSP00000020164, ENSMUST00000025897.12, OTTMUST00000044811
    Conserved Domains (3) summary
    smart00036
    Location:489801
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:16272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16272
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RNA

  1. NR_117093.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains an intron and uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC127556, AK011708, AK051036, BC034109, BY753233
    Related
    ENSMUST00000133696.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    6341117..6355619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531758.3XP_006531821.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X3

    Conserved Domains (3) summary
    smart00036
    Location:423735
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:37206
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:39206
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017318211.1XP_017173700.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83
    Conserved Domains (3) summary
    smart00036
    Location:445757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:39228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:38228
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006531760.3XP_006531823.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X4

    See identical proteins and their annotated locations for XP_006531823.1

    Conserved Domains (3) summary
    smart00036
    Location:400712
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1183
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017318212.1XP_017173701.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    Q14B83
    Conserved Domains (3) summary
    smart00036
    Location:445757
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:39228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:38228
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006531755.2XP_006531818.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531818.1

    Conserved Domains (3) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:48217
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006531756.2XP_006531819.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531819.1

    Conserved Domains (3) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:48217
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006531757.2XP_006531820.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006531820.1

    Conserved Domains (3) summary
    smart00036
    Location:434746
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:48217
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:50217
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001782591.1 RNA Sequence

    Related
    ENSMUST00000124556.7, OTTMUST00000044812

Reference GRCm38.p4 PATCHES

Genomic

  1. NW_012132910.1 Reference GRCm38.p4 PATCHES

    Range
    158077..172536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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