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GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens (human) ]

Gene ID: 2931, updated on 5-Dec-2021

Summary

Official Symbol
GSK3Aprovided by HGNC
Official Full Name
glycogen synthase kinase 3 alphaprovided by HGNC
Primary source
HGNC:HGNC:4616
See related
Ensembl:ENSG00000105723 MIM:606784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in brain (RPKM 26.3), testis (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

See GSK3A in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42230186..42243330, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42734342..42746754, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526 Neighboring gene ETS2 repressor factor Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene capicua transcriptional repressor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Incubation of human macrophages with exogenous HIV-1 Nef protein induces phosphorylation of Akt and GSK-3ss, and promotes IL-10 release PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686D0638

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac left ventricle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interleukin-3 ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dopamine receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in excitatory postsynaptic potential NAS
Non-traceable Author Statement
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of UDP-glucose catabolic process IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycogen (starch) synthase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of glycogen biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of glycogen synthase activity, transferring glucose-1-phosphate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type B pancreatic cell development TAS
Traceable Author Statement
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of amyloid-beta formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glycogen (starch) synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of systemic arterial blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in viral protein processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in apical dendrite NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of beta-catenin destruction complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in proximal dendrite NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glycogen synthase kinase-3 alpha
Names
GSK-3 alpha
serine/threonine-protein kinase GSK3A
NP_063937.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019884.3NP_063937.2  glycogen synthase kinase-3 alpha

    See identical proteins and their annotated locations for NP_063937.2

    Status: VALIDATED

    Source sequence(s)
    AC006486, BC027984, D63424, L40027
    Consensus CDS
    CCDS12599.1
    UniProtKB/Swiss-Prot
    P49840
    UniProtKB/TrEMBL
    A0A024R0L5
    Related
    ENSP00000222330.3, ENST00000222330.8
    Conserved Domains (2) summary
    cd14137
    Location:114406
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    pfam00069
    Location:119403
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42230186..42243330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001753673.1 RNA Sequence

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