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SLC25A6 solute carrier family 25 member 6 [ Homo sapiens (human) ]

Gene ID: 293, updated on 5-Sep-2021

Summary

Official Symbol
SLC25A6provided by HGNC
Official Full Name
solute carrier family 25 member 6provided by HGNC
Primary source
HGNC:HGNC:10992
See related
Ensembl:ENSG00000169100 MIM:300151; MIM:403000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y
Summary
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in kidney (RPKM 238.9), ovary (RPKM 226.6) and 25 other tissues See more
Orthologs
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Genomic context

See SLC25A6 in Genome Data Viewer
Location:
X;Y
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (1386152..1392113, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (1386152..1392113, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1505045..1511006, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1455045..1461006, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene uncharacterized LOC101928055 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 receptor subunit alpha Neighboring gene RNA, 5S ribosomal pseudogene 498 Neighboring gene uncharacterized LOC101928032 Neighboring gene uncharacterized LOC101928055 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP:ADP antiporter activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP/ATP translocase 3
Names
ADP,ATP carrier protein 3
ADP,ATP carrier protein, liver
ADP/ATP translocator of liver
adenine nucleotide translocator 3
epididymis secretory sperm binding protein
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013263.1 RefSeqGene

    Range
    5034..10995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001636.4NP_001627.2  ADP/ATP translocase 3

    See identical proteins and their annotated locations for NP_001627.2

    Status: REVIEWED

    Source sequence(s)
    BC007850, BC014775, CB150341
    Consensus CDS
    CCDS14114.1
    UniProtKB/Swiss-Prot
    P12236
    UniProtKB/TrEMBL
    Q6I9V5
    Related
    ENSP00000370808.5, ENST00000381401.11
    Conserved Domains (1) summary
    PTZ00169
    Location:3298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    1386152..1392113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    1386152..1392113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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