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Arfgef3 ARFGEF family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292947, updated on 17-Aug-2024

Summary

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Symbol
Arfgef3provided by RGD
Full Name
ARFGEF family member 3provided by RGD
Primary source
RGD:1309903
See related
EnsemblRapid:ENSRNOG00000011460 AllianceGenome:RGD:1309903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309903
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Orthologous to human ARFGEF3 (ARFGEF family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 158.7), Brain (RPKM 145.7) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arfgef3 in Genome Data Viewer
Location:
1p12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (15058574..15223742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (13245578..13404319, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (13837861..13918277, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene heme binding protein 2 Neighboring gene sperm motility kinase like 1 Neighboring gene p53 apoptosis effector related to PMP22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 3
Names
brefeldin A-inhibited guanine nucleotide-exchange protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427849.1 → NP_001414778.1  brefeldin A-inhibited guanine nucleotide-exchange protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZMK5, D3ZF86
    Related
    ENSRNOP00000079327.2, ENSRNOT00000103200.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    15058574..15223742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098805.2 → XP_038954733.1  brefeldin A-inhibited guanine nucleotide-exchange protein 3 isoform X1

    UniProtKB/TrEMBL
    D3ZF86
    Related
    ENSRNOP00000112704.1, ENSRNOT00000151285.1
    Conserved Domains (3) summary
    smart00222
    Location:539 → 751
    Sec7; Sec7 domain
    PLN03076
    Location:4 → 124
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    pfam09324
    Location:1198 → 1255
    DUF1981; Domain of unknown function (DUF1981)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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