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ARFGEF3 ARFGEF family member 3 [ Homo sapiens (human) ]

Gene ID: 57221, updated on 5-Aug-2018

Summary

Official Symbol
ARFGEF3provided by HGNC
Official Full Name
ARFGEF family member 3provided by HGNC
Primary source
HGNC:HGNC:21213
See related
Ensembl:ENSG00000112379 MIM:617411; Vega:OTTHUMG00000015670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIG3; A7322; C6orf92; PPP1R33; KIAA1244; dJ171N11.1
Expression
Broad expression in brain (RPKM 10.4), prostate (RPKM 8.3) and 15 other tissues See more
Orthologs

Genomic context

See ARFGEF3 in Genome Data Viewer
Location:
6q23.3-q24.1
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (138161690..138344663)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138483053..138665800)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378021 Neighboring gene PERP, TP53 apoptosis effector Neighboring gene prostate and breast cancer overexpressed 1 Neighboring gene small integral membrane protein 28 Neighboring gene MARCKS like 1 pseudogene 2 Neighboring gene heme binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32064, KIAA1244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 3
Names
protein phosphatase 1, regulatory subunit 33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020340.4NP_065073.3  brefeldin A-inhibited guanine nucleotide-exchange protein 3

    See identical proteins and their annotated locations for NP_065073.3

    Status: VALIDATED

    Source sequence(s)
    AB252196, BU682567
    Consensus CDS
    CCDS5189.2
    UniProtKB/Swiss-Prot
    Q5TH69
    Related
    ENSP00000251691.4, OTTHUMP00000017295, ENST00000251691.4, OTTHUMT00000042425
    Conserved Domains (4) summary
    smart00222
    Location:586798
    Sec7; Sec7 domain
    pfam03426
    Location:19762055
    CBM_15; Carbohydrate binding domain (family 15)
    pfam09324
    Location:12461303
    DUF1981; Domain of unknown function (DUF1981)
    pfam16213
    Location:5168
    DCB; Dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    138161690..138344663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001743524.1 RNA Sequence

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