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GRM5 glutamate metabotropic receptor 5 [ Homo sapiens (human) ]

Gene ID: 2915, updated on 5-Jan-2022

Summary

Official Symbol
GRM5provided by HGNC
Official Full Name
glutamate metabotropic receptor 5provided by HGNC
Primary source
HGNC:HGNC:4597
See related
Ensembl:ENSG00000168959 MIM:604102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mGlu5; GPRC1E; MGLUR5; PPP1R86
Summary
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Restricted expression toward brain (RPKM 10.2) See more
Orthologs
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Genomic context

See GRM5 in Genome Data Viewer
Location:
11q14.2-q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (88504576..89065982, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (88237810..88799150, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929174 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4758 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 70 Neighboring gene GRM5 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 16, pseudogene Neighboring gene uncharacterized LOC107984363 Neighboring gene tyrosinase 5' upstream regulatory sequence Neighboring gene tyrosinase Neighboring gene chromobox 3 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
GeneReviews: Not available
Common genetic variation and the control of HIV-1 in humans.
GeneReviews: Not available
Genome-wide association study in German patients with attention deficit/hyperactivity disorder.
GeneReviews: Not available
Genome-wide association study of tanning phenotype in a population of European ancestry.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM5 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling using intracellular calcium source IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of age-related behavioral decline ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of locomotion IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular calcium activated chloride channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of translation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of translational elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 5
Names
glutamate receptor, metabotropic 5
protein phosphatase 1, regulatory subunit 86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052831.1 RefSeqGene

    Range
    7294..566396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000842.5NP_000833.1  metabotropic glutamate receptor 5 isoform b precursor

    See identical proteins and their annotated locations for NP_000833.1

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Consensus CDS
    CCDS8283.1
    UniProtKB/Swiss-Prot
    P41594
    UniProtKB/TrEMBL
    A8K5P7
    Related
    ENSP00000405690.2, ENST00000455756.6
    Conserved Domains (4) summary
    cd15450
    Location:578827
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26497
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:508558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11311180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. NM_001143831.3NP_001137303.1  metabotropic glutamate receptor 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001137303.1

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Consensus CDS
    CCDS44694.1
    UniProtKB/Swiss-Prot
    P41594
    Related
    ENSP00000306138.4, ENST00000305447.5
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11621212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  3. NM_001384268.1NP_001371197.1  metabotropic glutamate receptor 5 isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Conserved Domains (4) summary
    cd15450
    Location:578827
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26497
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:508558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11311180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    88504576..89065982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542792.1XP_011541094.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011541094.1

    UniProtKB/Swiss-Prot
    P41594
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11621212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
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