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GRM5 glutamate metabotropic receptor 5 [ Homo sapiens (human) ]

Gene ID: 2915, updated on 18-Sep-2018

Summary

Official Symbol
GRM5provided by HGNC
Official Full Name
glutamate metabotropic receptor 5provided by HGNC
Primary source
HGNC:HGNC:4597
See related
Ensembl:ENSG00000168959 MIM:604102; Vega:OTTHUMG00000134306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mGlu5; GPRC1E; MGLUR5; PPP1R86
Summary
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Restricted expression toward brain (RPKM 10.2) See more
Orthologs

Genomic context

See GRM5 in Genome Data Viewer
Location:
11q14.2-q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (88504576..89065963, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (88237256..88796846, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929174 Neighboring gene cathepsin C Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 70 Neighboring gene GRM5 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 16, pseudogene Neighboring gene uncharacterized LOC107984363 Neighboring gene tyrosinase 5' upstream regulatory sequence Neighboring gene tyrosinase Neighboring gene chromobox 3 pseudogene 7

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
NHGRI GWA Catalog
Common genetic variation and the control of HIV-1 in humans.
NHGRI GWA Catalog
Genome-wide association study in German patients with attention deficit/hyperactivity disorder.
NHGRI GWA Catalog
Genome-wide association study of tanning phenotype in a population of European ancestry.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM5 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
    Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
  • Common Pathways Underlying Drug Addiction, organism-specific biosystem (from WikiPathways)
    Common Pathways Underlying Drug Addiction, organism-specific biosystemThe pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuro...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem (from WikiPathways)
    GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Long-term potentiation, organism-specific biosystem (from KEGG)
    Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Long-term potentiation, conserved biosystem (from KEGG)
    Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
calcium-mediated signaling using intracellular calcium source IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
modulation of age-related behavioral decline ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular calcium activated chloride channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translation TAS
Traceable Author Statement
more info
PubMed 
regulation of translational elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 5
Names
glutamate receptor, metabotropic 5
protein phosphatase 1, regulatory subunit 86

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052831.1 RefSeqGene

    Range
    7294..566396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000842.4NP_000833.1  metabotropic glutamate receptor 5 isoform b precursor

    See identical proteins and their annotated locations for NP_000833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has a longer 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant a. The encoded isoform (b, also known as mGluR5a) is shorter, compared to isoform a.
    Source sequence(s)
    AK291362, AP003120, DA316590
    Consensus CDS
    CCDS8283.1
    UniProtKB/Swiss-Prot
    P41594
    UniProtKB/TrEMBL
    A8K5P7
    Related
    ENSP00000405690.2, ENST00000455756.6
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11301180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. NM_001143831.2NP_001137303.1  metabotropic glutamate receptor 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001137303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (a, also known as mGluR5b).
    Source sequence(s)
    AP003120, BC031602, D28539
    Consensus CDS
    CCDS44694.1
    UniProtKB/Swiss-Prot
    P41594
    Related
    ENSP00000306138.4, OTTHUMP00000165957, ENST00000305447.4, OTTHUMT00000259226
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11621212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    88504576..89065963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017627.2XP_016873116.1  metabotropic glutamate receptor 5 isoform X2

    UniProtKB/Swiss-Prot
    P41594
    Related
    ENSP00000305905.5, OTTHUMP00000165953, ENST00000305432.9
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11301180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. XM_006718828.4XP_006718891.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_006718891.1

    UniProtKB/Swiss-Prot
    P41594
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11621212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  3. XM_011542792.1XP_011541094.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011541094.1

    UniProtKB/Swiss-Prot
    P41594
    Conserved Domains (5) summary
    cd06374
    Location:26497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11621212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
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