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GRM5 glutamate metabotropic receptor 5 [ Homo sapiens (human) ]

Gene ID: 2915, updated on 9-Sep-2025
Official Symbol
GRM5provided by HGNC
Official Full Name
glutamate metabotropic receptor 5provided by HGNC
Primary source
HGNC:HGNC:4597
See related
Ensembl:ENSG00000168959 MIM:604102; AllianceGenome:HGNC:4597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mGlu5; GPRC1E; MGLUR5; PPP1R86
Summary
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Restricted expression toward brain (RPKM 10.2) See more
Orthologs
mouse all
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Try the new Transcript table
See GRM5 in Genome Data Viewer
Location:
11q14.2-q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (88504642..89065982, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (88423789..88985122, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (88237810..88799150, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:88030550-88031243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5380 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:88040649-88041604 Neighboring gene MPRA-validated peak1386 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5381 Neighboring gene Sharpr-MPRA regulatory region 1780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5382 Neighboring gene uncharacterized LOC101929174 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4755 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5386 Neighboring gene cathepsin C Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 70 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3833 Neighboring gene Sharpr-MPRA regulatory region 7525 Neighboring gene GRM5 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 16, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr11:88521820-88522321 Neighboring gene tyrosinase 5' upstream regulatory sequence Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:88914222-88914816 Neighboring gene tyrosinase Neighboring gene CBX3 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 6977 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:89189921-89190421 Neighboring gene NADPH oxidase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89224088-89224794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89224795-89225501 Neighboring gene H3 histone pseudogene 34

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes. Iyer AM, et al. Curr Alzheimer Res, 2014. PMID 25115540
  2. mGluR5 stimulating Homer-PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species. Zhou L, et al. Exp Cell Res, 2013 Jun 10. PMID 23524143
  3. Glutamate receptors in human caudate nucleus in normal aging and Alzheimer's disease. Tsamis KI, et al. Curr Alzheimer Res, 2013 Jun. PMID 23627706
  4. Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans. Hulka LM, et al. Mol Psychiatry, 2014 May. PMID 23628984
  5. Distinct increased metabotropic glutamate receptor type 5 (mGluR5) in temporal lobe epilepsy with and without hippocampal sclerosis. Kandratavicius L, et al. Hippocampus, 2013 Dec. PMID 23804486, Free PMC Article

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use.
    Title: Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use.
  2. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.
    Title: Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.
  3. Stepwise activation of a metabotropic glutamate receptor.
    Title: Stepwise activation of a metabotropic glutamate receptor.
  4. Voltage tunes mGlu5 receptor function, impacting synaptic transmission.
    Title: Voltage tunes mGlu(5) receptor function, impacting synaptic transmission.
  5. Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [[18]F]PSS232 PET/MRI study.
    Title: Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: A [(18)F]PSS232 PET/MRI study.
  6. Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.
    Title: Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis.
  7. Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
    Title: Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
  8. Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.
    Title: Inhibition of mGluR5 ameliorates lipid accumulation and inflammation in HepG2 cells.
  9. From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.
    Title: From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.
  10. [Association of glutamate receptor metabotropic 5 polymorphisms with schizophrenia susceptibility in a Chinese Han population].
    Title: [Association of glutamate receptor metabotropic 5 polymorphisms with schizophrenia susceptibility in a Chinese Han population].
Submit: New GeneRIF Correction See all GeneRIFs (97)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
EBI GWAS Catalog
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genome-wide association study in German patients with attention deficit/hyperactivity disorder.
EBI GWAS Catalog
Genome-wide association study of tanning phenotype in a population of European ancestry.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM5 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables A2A adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within learning IEA
Inferred from Electronic Annotation
more info
  
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
  
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
metabotropic glutamate receptor 5
Names
glutamate receptor, metabotropic 5
protein phosphatase 1, regulatory subunit 86

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052831.1 RefSeqGene

    Range
    4990..566330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000842.5 → NP_000833.1  metabotropic glutamate receptor 5 isoform b precursor

    See identical proteins and their annotated locations for NP_000833.1

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Consensus CDS
    CCDS8283.1
    UniProtKB/TrEMBL
    K9J9K9
    Related
    ENSP00000405690.2, ENST00000455756.6
    Conserved Domains (4) summary
    cd15450
    Location:578 → 827
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26 → 497
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:508 → 558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:1131 → 1180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

  2. NM_001143831.3 → NP_001137303.1  metabotropic glutamate receptor 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001137303.1

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Consensus CDS
    CCDS44694.1
    UniProtKB/Swiss-Prot
    P41594, Q6J164
    UniProtKB/TrEMBL
    K9J9K9
    Related
    ENSP00000306138.4, ENST00000305447.5
    Conserved Domains (5) summary
    cd06374
    Location:26 → 497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591 → 824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67 → 472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508 → 557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:1162 → 1212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

  3. NM_001384268.1 → NP_001371197.1  metabotropic glutamate receptor 5 isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AP000626, AP001482, AP001828, AP003120, AP006215
    Consensus CDS
    CCDS8283.1
    UniProtKB/TrEMBL
    K9J9K9
    Conserved Domains (4) summary
    cd15450
    Location:578 → 827
    7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:26 → 497
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:508 → 558
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:1131 → 1180
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    88504642..89065982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542792.2 → XP_011541094.1  metabotropic glutamate receptor 5 isoform X1

    See identical proteins and their annotated locations for XP_011541094.1

    UniProtKB/Swiss-Prot
    P41594, Q6J164
    UniProtKB/TrEMBL
    K9J9K9
    Related
    ENSP00000632283.1, ENST00000962224.1
    Conserved Domains (5) summary
    cd06374
    Location:26 → 497
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:591 → 824
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67 → 472
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:508 → 557
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:1162 → 1212
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    88423789..88985122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368585.1 → XP_054224560.1  metabotropic glutamate receptor 5 isoform X1

    UniProtKB/Swiss-Prot
    P41594, Q6J164
    UniProtKB/TrEMBL
    K9J9K9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41594.2 GenPept UniProtKB/Swiss-Prot:P41594

Gene LinkOut

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