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Rpl17 ribosomal protein L17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291434, updated on 17-Aug-2024

Summary

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Symbol
Rpl17provided by RGD
Full Name
ribosomal protein L17provided by RGD
Primary source
RGD:1303019
See related
EnsemblRapid:ENSRNOG00000018680 AllianceGenome:RGD:1303019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ASI; rpL23
Summary
Enables large ribosomal subunit rRNA binding activity. Involved in cellular response to amino acid starvation and positive regulation of G1/S transition of mitotic cell cycle. Located in A band and nucleus. Part of cytosolic large ribosomal subunit and polysome. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 2031.6), Thymus (RPKM 1846.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70856275..70859388)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (68581141..68584253)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70969733..70972839)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 92 Neighboring gene solute carrier family 25 member 5, pseudogene 11 Neighboring gene small nucleolar RNA SNORD58 Neighboring gene small nucleolar RNA SNORD58 Neighboring gene similar to human chromosome 18 open reading frame 32 Neighboring gene small nucleolar RNA, C/D box 58B Neighboring gene U6 spliceosomal RNA Neighboring gene dymeclin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liver-specific induction of ribosomal protein gene expression by amino acid starvation in rats. Hitomi Y, et al. Biosci Biotechnol Biochem, 1993 Jul. PMID 7765311
  2. Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. Shay NF, et al. J Biol Chem, 1990 Oct 15. PMID 2211664
  3. Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation. Smolock EM, et al. Circulation, 2012 Nov 13. PMID 23065385, Free PMC Article
  4. Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25. Laine RO, et al. J Biol Chem, 1994 Apr 1. PMID 8144559
  5. The primary structure of rat ribosomal protein L17. Suzuki K, et al. Biochem Biophys Res Commun, 1991 Jul 15. PMID 2069571

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112577

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables large ribosomal subunit rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to amino acid starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL22
Names
60S ribosomal protein L17
L23
amino acid starvation-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201415.2 → NP_958818.1  large ribosomal subunit protein uL22

    See identical proteins and their annotated locations for NP_958818.1

    Status: VALIDATED

    Source sequence(s)
    FQ222545
    UniProtKB/Swiss-Prot
    P24049, Q4G093
    UniProtKB/TrEMBL
    A6KRH3, D3Z9G9
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    70856275..70859388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277168.1 → XP_063133238.1  large ribosomal subunit protein uL22 isoform X2

    UniProtKB/TrEMBL
    A6KRH4

  2. XM_039096639.2 → XP_038952567.1  large ribosomal subunit protein uL22 isoform X1

    UniProtKB/Swiss-Prot
    P24049, Q4G093
    UniProtKB/TrEMBL
    A6KRH3, D3Z9G9
    Conserved Domains (1) summary
    PTZ00178
    Location:1 → 165
    PTZ00178; 60S ribosomal protein L17; Provisional

  3. XM_063277167.1 → XP_063133237.1  large ribosomal subunit protein uL22 isoform X1

    UniProtKB/Swiss-Prot
    P24049, Q4G093
    UniProtKB/TrEMBL
    A6KRH3, D3Z9G9
    Related
    ENSRNOP00000025217.7, ENSRNOT00000025217.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24049.3 GenPept UniProtKB/Swiss-Prot:P24049

Gene LinkOut

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