Rpl17 ribosomal protein L17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpl17provided by MGI
Official Full Name: ribosomal protein L17provided by MGI
Primary source: MGI:MGI:2448270
See related: Ensembl:ENSMUSG00000062328 AllianceGenome:MGI:2448270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and positive regulation of G1/S transition of mitotic cell cycle. Located in synapse. Is expressed in brain; central nervous system; embryo; pancreas epithelium; and retina. Orthologous to several human genes including RPL17-C18orf32 (RPL17-C18orf32 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 250.7), bladder adult (RPKM 230.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18; 18 E3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (75132049..75136452)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (74998978..75003381)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reducing the amount of Rpl17 in mouse cells led to stalled 60S subunit maturation, causing degradation of most of the synthesized precursors
Title: Reduced expression of the mouse ribosomal protein Rpl17 alters the diversity of mature ribosomes by enhancing production of shortened 5.8S rRNA.
Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.
Title: Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI286279 (e-PCR)
- UniSTS:245288

D17S1714 (e-PCR)
- UniSTS:79056

Homology

Homologs of the Rpl17 gene: The Rpl17 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 352 organisms have orthologs with human gene Rpl17
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables large ribosomal subunit rRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in A band	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of large ribosomal subunit	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of polysome	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 60S ribosomal protein L17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002239.4 → NP_001002239.2 60S ribosomal protein L17 isoform a

See identical proteins and their annotated locations for NP_001002239.2

Status: VALIDATED

Source sequence(s)

AC125122

Consensus CDS

CCDS29344.1

UniProtKB/TrEMBL

A0A6P7QI27, A0A8C6HIW1, Q6ZWZ7

Related

ENSMUSP00000078654.6, ENSMUST00000079716.6

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
NM_001405964.1 → NP_001392893.1 60S ribosomal protein L17 isoform a

Status: VALIDATED

Source sequence(s)

AC125122

UniProtKB/TrEMBL

A0A6P7QI27, A0A8C6HIW1, Q6ZWZ7
NM_001405965.1 → NP_001392894.1 60S ribosomal protein L17 isoform b

Status: VALIDATED

Source sequence(s)

AC125122
NM_001405966.1 → NP_001392895.1 60S ribosomal protein L17 isoform c

Status: VALIDATED

Source sequence(s)

AC125122

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

75132049..75136452

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525996.1 → XP_006526059.1 60S ribosomal protein L17 isoform X2

See identical proteins and their annotated locations for XP_006526059.1

UniProtKB/TrEMBL

A0A6P7QI27, A0A8C6HIW1, Q6ZWZ7

Related

ENSMUSP00000157556.2, ENSMUST00000237431.2

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
XM_036161166.1 → XP_036017059.1 60S ribosomal protein L17 isoform X3

Conserved Domains (1) summary

PTZ00178
Location:1 → 127

PTZ00178; 60S ribosomal protein L17; Provisional
XM_017317919.3 → XP_017173408.1 60S ribosomal protein L17 isoform X2

UniProtKB/TrEMBL

Q6ZWZ7

Conserved Domains (1) summary

PTZ00178
Location:1 → 165

PTZ00178; 60S ribosomal protein L17; Provisional
XM_017317918.2 → XP_017173407.1 60S ribosomal protein L17 isoform X1

Conserved Domains (1) summary

PTZ00178
Location:45 → 182

PTZ00178; 60S ribosomal protein L17; Provisional