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SAP30BP SAP30 binding protein [ Homo sapiens (human) ]

Gene ID: 29115, updated on 2-Oct-2018

Summary

Official Symbol
SAP30BPprovided by HGNC
Official Full Name
SAP30 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:30785
See related
Ensembl:ENSG00000161526 MIM:610218; Vega:OTTHUMG00000179798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTRG; HTRP; HCNGP
Expression
Ubiquitous expression in bone marrow (RPKM 20.7), brain (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See SAP30BP in Genome Data Viewer
Location:
17q25.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (75667116..75708062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73663399..73704139)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 5 Neighboring gene uncharacterized LOC107985013 Neighboring gene small integral membrane protein 6 Neighboring gene ITGB4 intron CAGE-defined low expression enhancer Neighboring gene integrin subunit beta 4 Neighboring gene galactokinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SAP30 binding protein (SAP30BP) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Negative epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Negative epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughl...
  • NoRC negatively regulates rRNA expression, organism-specific biosystem (from REACTOME)
    NoRC negatively regulates rRNA expression, organism-specific biosystemOnly about half of the rRNA gene copies in a cell are expressed. The remaining copies are silenced by modifications to histones and DNA (reviewed in Santoro and Grummt 2001, Grummt 2007, Preuss and P...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40928, DKFZp586L2022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SAP30-binding protein
Names
HSV-1 binding
transcriptional regulator protein HCNGP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301839.1NP_001288768.1  SAP30-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001288768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive alternate in-frame exons in the 5' coding region compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC087749, AF450482, AK095265, BC011724
    Consensus CDS
    CCDS77115.1
    UniProtKB/Swiss-Prot
    Q9UHR5
    Related
    ENSP00000347592.3, OTTHUMP00000262404, ENST00000355423.7, OTTHUMT00000448230
    Conserved Domains (1) summary
    pfam07818
    Location:103194
    HCNGP; HCNGP-like protein
  2. NM_001301855.1NP_001288784.1  SAP30-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001288784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC087749, AF450482, BC011724, BM807177
    UniProtKB/Swiss-Prot
    Q9UHR5
    Related
    ENSP00000463758.1, OTTHUMP00000262411, ENST00000583536.5, OTTHUMT00000448243
    Conserved Domains (1) summary
    pfam07818
    Location:153244
    HCNGP; HCNGP-like protein
  3. NM_013260.7NP_037392.1  SAP30-binding protein isoform 2

    See identical proteins and their annotated locations for NP_037392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC087749, AF450482, BC011724
    Consensus CDS
    CCDS11726.1
    UniProtKB/Swiss-Prot
    Q9UHR5
    UniProtKB/TrEMBL
    A0A024R8R0
    Related
    ENSP00000462116.1, OTTHUMP00000262402, ENST00000584667.5, OTTHUMT00000448227
    Conserved Domains (1) summary
    pfam07818
    Location:119210
    HCNGP; HCNGP-like protein

RNA

  1. NR_126036.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087749, AF450482, BC011724
    Related
    ENST00000582022.5, OTTHUMT00000448241
  2. NR_126037.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087749, AF450482, AK298060, BC011724

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    75667116..75708062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024545.1XP_016880034.1  SAP30-binding protein isoform X4

  2. XM_017024547.1XP_016880036.1  SAP30-binding protein isoform X6

  3. XM_024450735.1XP_024306503.1  SAP30-binding protein isoform X5

    Conserved Domains (1) summary
    pfam07818
    Location:97188
    HCNGP; HCNGP-like protein
  4. XM_011524694.2XP_011522996.1  SAP30-binding protein isoform X2

    See identical proteins and their annotated locations for XP_011522996.1

    Conserved Domains (1) summary
    pfam07818
    Location:103189
    HCNGP; HCNGP-like protein
  5. XM_011524695.2XP_011522997.1  SAP30-binding protein isoform X3

    Conserved Domains (1) summary
    pfam07818
    Location:97183
    HCNGP; HCNGP-like protein
  6. XM_017024548.1XP_016880037.1  SAP30-binding protein isoform X7

  7. XM_017024549.1XP_016880038.1  SAP30-binding protein isoform X8

  8. XM_011524693.3XP_011522995.1  SAP30-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011522995.1

    Conserved Domains (1) summary
    pfam07818
    Location:119205
    HCNGP; HCNGP-like protein
  9. XM_017024550.1XP_016880039.1  SAP30-binding protein isoform X9

    Conserved Domains (1) summary
    pfam07818
    Location:528
    HCNGP; HCNGP-like protein

RNA

  1. XR_002957993.1 RNA Sequence

  2. XR_001752502.2 RNA Sequence

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