Format

Send to:

Choose Destination

MED4 mediator complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 29079, updated on 7-Jun-2020

Summary

Official Symbol
MED4provided by HGNC
Official Full Name
mediator complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:17903
See related
Ensembl:ENSG00000136146 MIM:605718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC36; VDRIP; DRIP36; TRAP36; HSPC126
Summary
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See MED4 in Genome Data Viewer
Location:
13q14.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (48075724..48095141, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48649864..48669277, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 15 Neighboring gene Sharpr-MPRA regulatory region 3717 Neighboring gene MED4 antisense RNA 1 Neighboring gene uncharacterized LOC105370198 Neighboring gene RNA polymerase II subunit K pseudogene 2 Neighboring gene integral membrane protein 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 4 (MED4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 4 (MED4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED4 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 4
Names
TRAP/SMCC/PC2 subunit p36
activator-recruited cofactor 36 kDa component
mediator, 34-kD subunit, homolog
vitamin D receptor-interacting protein, 36-kD
vitamin D3 receptor-interacting protein complex 36 kDa component

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270629.1NP_001257558.1  mediator of RNA polymerase II transcription subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001257558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI613470, AK301835, AL158196, BP309440
    Consensus CDS
    CCDS59241.1
    UniProtKB/Swiss-Prot
    Q9NPJ6
    Related
    ENSP00000367849.1, ENST00000378586.5
    Conserved Domains (1) summary
    pfam10018
    Location:18156
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
  2. NM_014166.4NP_054885.1  mediator of RNA polymerase II transcription subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_054885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI613470, AK001934, AL158196
    Consensus CDS
    CCDS9408.1
    UniProtKB/Swiss-Prot
    Q9NPJ6
    UniProtKB/TrEMBL
    A0A024RDY7
    Related
    ENSP00000258648.2, ENST00000258648.7
    Conserved Domains (1) summary
    pfam10018
    Location:64202
    Med4; Vitamin-D-receptor interacting Mediator subunit 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    48075724..48095141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020549.1XP_016876038.1  mediator of RNA polymerase II transcription subunit 4 isoform X1

    Related
    ENSP00000413595.1, ENST00000417167.2
Support Center