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MED4 mediator complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 29079, updated on 27-Nov-2024

Summary

Official Symbol
MED4provided by HGNC
Official Full Name
mediator complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:17903
See related
Ensembl:ENSG00000136146 MIM:605718; AllianceGenome:HGNC:17903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC36; VDRIP; DRIP36; TRAP36; HSPC126
Summary
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

See MED4 in Genome Data Viewer
Location:
13q14.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48075724..48095104, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47296104..47315464, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48649860..48669240, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:48575750-48576949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:48577621-48578218 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:48578817-48579414 Neighboring gene SUCLA2 antisense RNA 1 Neighboring gene uncharacterized LOC124903172 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:48610990-48611866 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:48611867-48612742 Neighboring gene nudix hydrolase 15 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:48640162-48641361 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:48646101-48647300 Neighboring gene MED4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5997 Neighboring gene uncharacterized LOC105370198 Neighboring gene RNA polymerase II subunit K pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7723 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:48733841-48734451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7724 Neighboring gene Sharpr-MPRA regulatory region 1366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5332 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:48807853-48808550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:48809655-48810242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:48815437-48815937 Neighboring gene integral membrane protein 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 4 (MED4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 4 (MED4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED4 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear receptor coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 
enables nuclear vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 4
Names
activator-recruited cofactor 36 kDa component
mediator, 34-kD subunit, homolog
vitamin D receptor-interacting protein, 36-kD
vitamin D3 receptor-interacting protein complex 36 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270629.2NP_001257558.1  mediator of RNA polymerase II transcription subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001257558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI613470, AK301835, AL158196
    Consensus CDS
    CCDS59241.1
    UniProtKB/TrEMBL
    Q5T911
    Related
    ENSP00000367849.1, ENST00000378586.5
    Conserved Domains (1) summary
    pfam10018
    Location:18143
    Med4; Vitamin-D-receptor interacting Mediator subunit 4
  2. NM_014166.4NP_054885.1  mediator of RNA polymerase II transcription subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_054885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI613470, AK001934, AL158196
    Consensus CDS
    CCDS9408.1
    UniProtKB/Swiss-Prot
    B4DX67, Q53GB4, Q53H68, Q5T912, Q6FHC4, Q6IA79, Q9BS95, Q9NPJ6, Q9NYR5
    UniProtKB/TrEMBL
    U4PSC4
    Related
    ENSP00000258648.2, ENST00000258648.7
    Conserved Domains (1) summary
    pfam10018
    Location:64189
    Med4; Vitamin-D-receptor interacting Mediator subunit 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    48075724..48095104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    47296104..47315464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)