U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZC3H7A zinc finger CCCH-type containing 7A [ Homo sapiens (human) ]

Gene ID: 29066, updated on 7-Sep-2023

Summary

Go to the top of the page Help
Official Symbol
ZC3H7Aprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:30959
See related
Ensembl:ENSG00000122299 MIM:619819; AllianceGenome:HGNC:30959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H7; HSPC055; ZC3HDC7
Summary
Enables miRNA binding activity. Involved in production of miRNAs involved in gene silencing by miRNA. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZC3H7A in Genome Data Viewer
Location:
16p13.13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11750597..11797258, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11786640..11833292, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11844453..11891114, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903643 Neighboring gene Sharpr-MPRA regulatory region 8349 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11735633-11736296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11766535-11767354 Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene thioredoxin domain containing 11 Neighboring gene stannin Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene ribosomal L1 domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of new high affinity targets for Roquin based on structural conservation. Braun J, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295819, Free PMC Article
  2. Common variants at ten loci influence QT interval duration in the QTGEN Study. Newton-Cheh C, et al. Nat Genet, 2009 Apr. PMID 19305408, Free PMC Article
  3. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, et al. Cell Rep, 2019 Apr 16. PMID 30995489
  4. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. Hunter MR, et al. J Mol Biol, 2018 Jul 6. PMID 29778605, Free PMC Article
  5. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Treiber T, et al. Mol Cell, 2017 Apr 20. PMID 28431233

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10027, FLJ20318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger CCCH domain-containing protein 7A
Names
zinc finger CCCH-type domain containing 7
zinc-finger protein AY163807

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014153.4 → NP_054872.2  zinc finger CCCH domain-containing protein 7A

    See identical proteins and their annotated locations for NP_054872.2

    Status: VALIDATED

    Source sequence(s)
    AY163807, BC046363, DA160892
    Consensus CDS
    CCDS10550.1
    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Related
    ENSP00000347999.4, ENST00000355758.9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11750597..11797258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522463.3 → XP_011520765.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_011520765.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

  2. XM_047433996.1 → XP_047289952.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  3. XM_006720877.3 → XP_006720940.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_006720940.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906 → 926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44 → 119
    TPR_11; TPR repeat

  4. XM_017023174.2 → XP_016878663.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_011522464.3 → XP_011520766.1  zinc finger CCCH domain-containing protein 7A isoform X4

    Conserved Domains (3) summary
    smart00356
    Location:667 → 687
    ZnF_C3H1; zinc finger
    sd00020
    Location:620 → 642
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:618 → 643
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  6. XM_047433998.1 → XP_047289954.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_047433997.1 → XP_047289953.1  zinc finger CCCH domain-containing protein 7A isoform X3

    UniProtKB/TrEMBL
    I3L2K5
    Related
    ENSP00000459747.1, ENST00000571198.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11786640..11833292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380153.1 → XP_054236128.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  2. XM_054380155.1 → XP_054236130.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  3. XM_054380154.1 → XP_054236129.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9

  4. XM_054380156.1 → XP_054236131.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_054380158.1 → XP_054236133.1  zinc finger CCCH domain-containing protein 7A isoform X4

  6. XM_054380159.1 → XP_054236134.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_054380157.1 → XP_054236132.1  zinc finger CCCH domain-containing protein 7A isoform X3

    UniProtKB/TrEMBL
    I3L2K5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWR0.1 GenPept UniProtKB/Swiss-Prot:Q8IWR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous