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ZC3H7A zinc finger CCCH-type containing 7A [ Homo sapiens (human) ]

Gene ID: 29066, updated on 17-Jun-2024

Summary

Official Symbol
ZC3H7Aprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 7Aprovided by HGNC
Primary source
HGNC:HGNC:30959
See related
Ensembl:ENSG00000122299 MIM:619819; AllianceGenome:HGNC:30959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H7; HSPC055; ZC3HDC7
Summary
Enables miRNA binding activity. Involved in production of miRNAs involved in gene silencing by miRNA. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZC3H7A in Genome Data Viewer
Location:
16p13.13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11750597..11797258, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11786640..11833292, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11844453..11891114, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11836693-11837215 Neighboring gene TXNDC11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene ribosomal L1 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10027, FLJ20318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 7A
Names
zinc finger CCCH-type domain containing 7
zinc-finger protein AY163807

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014153.4NP_054872.2  zinc finger CCCH domain-containing protein 7A

    See identical proteins and their annotated locations for NP_054872.2

    Status: VALIDATED

    Source sequence(s)
    AY163807, BC046363, DA160892
    Consensus CDS
    CCDS10550.1
    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Related
    ENSP00000347999.4, ENST00000355758.9
    Conserved Domains (5) summary
    smart00356
    Location:906926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:4671
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44119
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11750597..11797258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522463.3XP_011520765.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_011520765.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:4671
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44119
    TPR_11; TPR repeat
  2. XM_047433996.1XP_047289952.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
  3. XM_006720877.3XP_006720940.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_006720940.1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
    Conserved Domains (5) summary
    smart00356
    Location:906926
    ZnF_C3H1; zinc finger
    sd00020
    Location:859881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:4671
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:44119
    TPR_11; TPR repeat
  4. XM_017023174.2XP_016878663.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_011522464.3XP_011520766.1  zinc finger CCCH domain-containing protein 7A isoform X4

    Conserved Domains (3) summary
    smart00356
    Location:667687
    ZnF_C3H1; zinc finger
    sd00020
    Location:620642
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:618643
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
  6. XM_047433998.1XP_047289954.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_047433997.1XP_047289953.1  zinc finger CCCH domain-containing protein 7A isoform X3

    UniProtKB/TrEMBL
    I3L2K5
    Related
    ENSP00000459747.1, ENST00000571198.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11786640..11833292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380153.1XP_054236128.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
  2. XM_054380155.1XP_054236130.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
  3. XM_054380154.1XP_054236129.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/Swiss-Prot
    D3DUG5, Q8IWR0, Q9NPE9
  4. XM_054380156.1XP_054236131.1  zinc finger CCCH domain-containing protein 7A isoform X2

  5. XM_054380158.1XP_054236133.1  zinc finger CCCH domain-containing protein 7A isoform X4

  6. XM_054380159.1XP_054236134.1  zinc finger CCCH domain-containing protein 7A isoform X5

  7. XM_054380157.1XP_054236132.1  zinc finger CCCH domain-containing protein 7A isoform X3

    UniProtKB/TrEMBL
    I3L2K5