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GRIK5 glutamate ionotropic receptor kainate type subunit 5 [ Homo sapiens (human) ]

Gene ID: 2901, updated on 2-Oct-2018

Summary

Official Symbol
GRIK5provided by HGNC
Official Full Name
glutamate ionotropic receptor kainate type subunit 5provided by HGNC
Primary source
HGNC:HGNC:4583
See related
Ensembl:ENSG00000105737 MIM:600283; Vega:OTTHUMG00000044573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KA2; EAA2; GRIK2; GluK5
Summary
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues See more
Orthologs

Genomic context

See GRIK5 in Genome Data Viewer
Location:
19q13.2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (41998316..42071804, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42502468..42574278, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene zinc finger protein 574 Neighboring gene POU class 2 homeobox 2 Neighboring gene uncharacterized LOC100505622 Neighboring gene microRNA 4323 Neighboring gene death effector domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-gated ion channel activity TAS
Traceable Author Statement
more info
 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein retention in ER lumen IEA
Inferred from Electronic Annotation
more info
 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, kainate 5
Names
excitatory amino acid receptor 2
glutamate receptor KA2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301030.1NP_001287959.1  glutamate receptor ionotropic, kainate 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001287959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010616, AJ249209, BM152516
    Consensus CDS
    CCDS77305.1
    UniProtKB/Swiss-Prot
    Q16478
    Related
    ENSP00000301218.3, OTTHUMP00000042062, ENST00000301218.8, OTTHUMT00000104008
    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:545815
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414784
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. NM_002088.4NP_002079.3  glutamate receptor ionotropic, kainate 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002079.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    BC037358, BC131717, CA432656
    Consensus CDS
    CCDS12595.1
    UniProtKB/Swiss-Prot
    Q16478
    Related
    ENSP00000262895.2, OTTHUMP00000270054, ENST00000262895.7, OTTHUMT00000463453
    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:545815
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414784
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    41998316..42071804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258821.3XP_005258878.1  glutamate receptor ionotropic, kainate 5 isoform X3

    See identical proteins and their annotated locations for XP_005258878.1

    UniProtKB/Swiss-Prot
    Q16478
    Related
    ENSP00000470251.1, OTTHUMP00000270055, ENST00000593562.5, OTTHUMT00000463454
    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:545815
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414784
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. XM_011526862.2XP_011525164.1  glutamate receptor ionotropic, kainate 5 isoform X1

    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:546816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414785
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_011526868.1XP_011525170.1  glutamate receptor ionotropic, kainate 5 isoform X7

    Conserved Domains (4) summary
    pfam00060
    Location:465735
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:1298
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:1318
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:333704
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  4. XM_011526865.1XP_011525167.1  glutamate receptor ionotropic, kainate 5 isoform X4

    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:546816
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414785
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  5. XM_011526867.1XP_011525169.1  glutamate receptor ionotropic, kainate 5 isoform X6

    Conserved Domains (4) summary
    pfam00060
    Location:477747
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:13311
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:14331
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:346716
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  6. XM_017026713.1XP_016882202.1  glutamate receptor ionotropic, kainate 5 isoform X5

    Conserved Domains (4) summary
    pfam00060
    Location:478748
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:13311
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:14331
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:346717
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  7. XM_011526863.2XP_011525165.1  glutamate receptor ionotropic, kainate 5 isoform X2

    See identical proteins and their annotated locations for XP_011525165.1

    UniProtKB/Swiss-Prot
    Q16478
    Conserved Domains (4) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam00060
    Location:545815
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414784
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  8. XM_011526869.2XP_011525171.1  glutamate receptor ionotropic, kainate 5 isoform X8

    Conserved Domains (3) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414613
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  9. XM_011526871.2XP_011525173.1  glutamate receptor ionotropic, kainate 5 isoform X10

    Conserved Domains (3) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414491
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  10. XM_011526870.2XP_011525172.1  glutamate receptor ionotropic, kainate 5 isoform X9

    Conserved Domains (3) summary
    cd06394
    Location:25399
    PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
    pfam01094
    Location:42379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414491
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_935810.2 RNA Sequence

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