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MRPL13 mitochondrial ribosomal protein L13 [ Homo sapiens (human) ]

Gene ID: 28998, updated on 3-May-2020

Summary

Official Symbol
MRPL13provided by HGNC
Official Full Name
mitochondrial ribosomal protein L13provided by HGNC
Primary source
HGNC:HGNC:14278
See related
Ensembl:ENSG00000172172 MIM:610200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L13; L13A; L13mt; RPL13; RPML13
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 20.3), kidney (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See MRPL13 in Genome Data Viewer
Location:
8q24.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (120395437..120445150, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121408083..121457647, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375730 Neighboring gene collagen type XIV alpha 1 chain Neighboring gene MDM2 binding protein Neighboring gene syntrophin beta 1 Neighboring gene non-SMC condensin I complex subunit G pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L13, mitochondrial
Names
MRP-L13
mitochondrial large ribosomal subunit protein uL13m
NP_054797.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014078.6NP_054797.2  39S ribosomal protein L13, mitochondrial

    See identical proteins and their annotated locations for NP_054797.2

    Status: REVIEWED

    Source sequence(s)
    AC107877, BC021744, CN362173
    Consensus CDS
    CCDS6332.1
    UniProtKB/Swiss-Prot
    Q9BYD1
    Related
    ENSP00000306548.3, ENST00000306185.8
    Conserved Domains (1) summary
    pfam00572
    Location:18140
    Ribosomal_L13; Ribosomal protein L13

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    120395437..120445150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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