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MACROD1 MACRO domain containing 1 [ Homo sapiens (human) ]

Gene ID: 28992, updated on 2-Oct-2018

Summary

Official Symbol
MACROD1provided by HGNC
Official Full Name
MACRO domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29598
See related
Ensembl:ENSG00000133315 MIM:610400; Vega:OTTHUMG00000167843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP16
Expression
Broad expression in kidney (RPKM 9.5), prostate (RPKM 2.7) and 22 other tissues See more
Orthologs

Genomic context

See MACROD1 in Genome Data Viewer
Location:
11q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (63998554..64166652, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63766006..63933602, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene uncharacterized LOC101927673 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene uncharacterized LOC105369339 Neighboring gene stress induced phosphoprotein 1 Neighboring gene fermitin family member 3 Neighboring gene tRNA phosphotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein de-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleoside metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
O-acetyl-ADP-ribose deacetylase MACROD1
Names
MACRO domain-containing protein 1
[Protein ADP-ribosylglutamate] hydrolase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014067.3NP_054786.2  O-acetyl-ADP-ribose deacetylase MACROD1

    See identical proteins and their annotated locations for NP_054786.2

    Status: VALIDATED

    Source sequence(s)
    AF202922, BC003188, BQ637198
    Consensus CDS
    CCDS8056.1
    UniProtKB/Swiss-Prot
    Q9BQ69
    Related
    ENSP00000255681.6, OTTHUMP00000237037, ENST00000255681.6, OTTHUMT00000396570
    Conserved Domains (2) summary
    COG2110
    Location:152314
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:153319
    Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    63998554..64166652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544970.2XP_011543272.1  O-acetyl-ADP-ribose deacetylase MACROD1 isoform X2

    Conserved Domains (2) summary
    COG2110
    Location:152304
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:153309
    Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
  2. XM_005273939.4XP_005273996.1  O-acetyl-ADP-ribose deacetylase MACROD1 isoform X1

    Conserved Domains (2) summary
    COG2110
    Location:152314
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:153319
    Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
  3. XM_006718521.3XP_006718584.1  O-acetyl-ADP-ribose deacetylase MACROD1 isoform X3

    Conserved Domains (1) summary
    cl00019
    Location:153178
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  4. XM_006718522.2XP_006718585.1  O-acetyl-ADP-ribose deacetylase MACROD1 isoform X5

    Conserved Domains (1) summary
    cl00019
    Location:153172
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  5. XM_005273940.2XP_005273997.1  O-acetyl-ADP-ribose deacetylase MACROD1 isoform X4

    Conserved Domains (1) summary
    cl00019
    Location:153172
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
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