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Macrod1 mono-ADP ribosylhydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 107227, updated on 5-Mar-2024

Summary

Official Symbol
Macrod1provided by MGI
Official Full Name
mono-ADP ribosylhydrolase 1provided by MGI
Primary source
MGI:MGI:2147583
See related
Ensembl:ENSMUSG00000036278 AllianceGenome:MGI:2147583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrp16; D930010J01Rik
Summary
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in mitochondrion. Orthologous to human MACROD1 (mono-ADP ribosylhydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 26.0), adrenal adult (RPKM 22.0) and 21 other tissues See more
Orthologs
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Genomic context

See Macrod1 in Genome Data Viewer
Location:
19 A; 19 5.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7034065..7175427)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7056728..7198062)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052 Neighboring gene STARR-seq mESC enhancer starr_45447 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_45448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7140992-7141179 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7190709-7190892 Neighboring gene predicted gene, 38621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7238874-7239062 Neighboring gene STARR-positive B cell enhancer ABC_E8735 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene cytochrome c oxidase subunit 8A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-ribosylglutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ADP-ribosylglutamate hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-glutamate ADP-deribosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-glutamate ADP-deribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein de-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleoside metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in purine nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribose glycohydrolase MACROD1
Names
MACRO domain containing 1
MACRO domain-containing protein 1
O-acetyl-ADP-ribose deacetylase MACROD1
[Protein ADP-ribosylaspartate] hydrolase MACROD1
[Protein ADP-ribosylglutamate] hydrolase
[Protein ADP-ribosylglutamate] hydrolase MACROD1
NP_001365848.1
NP_001365849.1
NP_001390467.1
NP_001390469.1
NP_598908.2
XP_006526626.1
XP_036017267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378919.1NP_001365848.1  ADP-ribose glycohydrolase MACROD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109619, AC140307
    Conserved Domains (1) summary
    cd02908
    Location:151317
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
  2. NM_001378920.1NP_001365849.1  ADP-ribose glycohydrolase MACROD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109619
    Conserved Domains (1) summary
    cl00019
    Location:151170
    Macro_SF; macrodomain superfamily
  3. NM_001403538.1NP_001390467.1  ADP-ribose glycohydrolase MACROD1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109619, AC140307
  4. NM_001403540.1NP_001390469.1  ADP-ribose glycohydrolase MACROD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109619, AC140307
  5. NM_134147.5NP_598908.2  ADP-ribose glycohydrolase MACROD1 isoform 1

    See identical proteins and their annotated locations for NP_598908.2

    Status: VALIDATED

    Source sequence(s)
    AC109619, AC140307
    Consensus CDS
    CCDS50376.1
    UniProtKB/Swiss-Prot
    Q922B1
    Related
    ENSMUSP00000039507.6, ENSMUST00000040261.7
    Conserved Domains (2) summary
    COG2110
    Location:150314
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:151317
    Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7034065..7175427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161374.1XP_036017267.1  ADP-ribose glycohydrolase MACROD1 isoform X1

    Conserved Domains (1) summary
    cd02908
    Location:151317
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
  2. XM_006526563.4XP_006526626.1  ADP-ribose glycohydrolase MACROD1 isoform X2

    Conserved Domains (1) summary
    cl00019
    Location:149306
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...