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DBNL drebrin like [ Homo sapiens (human) ]

Gene ID: 28988, updated on 7-Oct-2018

Summary

Official Symbol
DBNLprovided by HGNC
Official Full Name
drebrin likeprovided by HGNC
Primary source
HGNC:HGNC:2696
See related
Ensembl:ENSG00000136279 MIM:610106; Vega:OTTHUMG00000155350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABP1; HIP55; SH3P7; HIP-55
Expression
Ubiquitous expression in esophagus (RPKM 54.1), spleen (RPKM 52.7) and 25 other tissues See more
Orthologs

Genomic context

See DBNL in Genome Data Viewer
Location:
7p13
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (44044640..44061913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44084239..44101315)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit J4, pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member E1 Neighboring gene RAS p21 protein activator 4C, pseudogene Neighboring gene long intergenic non-protein coding RNA 957 Neighboring gene microRNA 6837 Neighboring gene phosphoglycerate mutase 2 Neighboring gene microRNA 6838 Neighboring gene DNA polymerase mu

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
    Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • JNK signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
    JNK signaling in the CD4+ TCR pathway, organism-specific biosystem
    JNK signaling in the CD4+ TCR pathway
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cadherin binding HDA PubMed 
enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rac protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
podosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
podosome ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
drebrin-like protein
Names
HPK1-interacting protein of 55 kDa
SH3 domain-containing protein 7
actin-binding protein 1
cervical SH3P7
cervical mucin-associated protein
drebrin-F
src homology 3 domain-containing protein HIP-55

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014436.2NP_001014436.1  drebrin-like protein isoform b

    See identical proteins and their annotated locations for NP_001014436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AF077353, BC011677, DC404852
    Consensus CDS
    CCDS34623.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000411701.1, OTTHUMP00000207761, ENST00000448521.5, OTTHUMT00000339572
    Conserved Domains (3) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:375428
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl27169
    Location:225374
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
  2. NM_001122956.1NP_001116428.1  drebrin-like protein isoform c

    See identical proteins and their annotated locations for NP_001116428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AK027367, BC011677, DC404852
    Consensus CDS
    CCDS47579.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000417653.1, OTTHUMP00000214096, ENST00000468694.5, OTTHUMT00000353344
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:384437
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  3. NM_001284313.1NP_001271242.1  drebrin-like protein isoform d

    See identical proteins and their annotated locations for NP_001271242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons, uses an alternate in-frame splice site and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform c.
    Source sequence(s)
    AC017116, AF218020, AK293698
    Consensus CDS
    CCDS64634.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000415173.1, OTTHUMP00000207764, ENST00000440166.5, OTTHUMT00000339575
    Conserved Domains (2) summary
    cd11960
    Location:272325
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl15697
    Location:135
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. NM_001284315.1NP_001271244.1  drebrin-like protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus compared to isoform c.
    Source sequence(s)
    AC017116, AF218020, AK300630
    Consensus CDS
    CCDS64633.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    UniProtKB/TrEMBL
    B4DUF9
    Related
    ENSP00000417749.2, ENST00000490734.6
    Conserved Domains (2) summary
    cd11960
    Location:281334
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl15697
    Location:1543
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  5. NM_001362723.1NP_001349652.1  drebrin-like protein isoform f

    Status: VALIDATED

    Source sequence(s)
    AK027367, BC011677, DC404852, DT220937
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:383436
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  6. NM_014063.6NP_054782.2  drebrin-like protein isoform a

    See identical proteins and their annotated locations for NP_054782.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    BC011677, DC404852
    Consensus CDS
    CCDS34622.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000419992.1, OTTHUMP00000214095, ENST00000494774.5, OTTHUMT00000353343
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:376429
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    44044640..44061913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515325.2XP_011513627.1  drebrin-like protein isoform X1

    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:383436
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
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