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DBNL drebrin like [ Homo sapiens (human) ]

Gene ID: 28988, updated on 4-Dec-2022

Summary

Official Symbol
DBNLprovided by HGNC
Official Full Name
drebrin likeprovided by HGNC
Primary source
HGNC:HGNC:2696
See related
Ensembl:ENSG00000136279 MIM:610106; AllianceGenome:HGNC:2696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABP1; HIP55; SH3P7; HIP-55
Summary
Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 54.1), spleen (RPKM 52.7) and 25 other tissues See more
Orthologs
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Genomic context

See DBNL in Genome Data Viewer
Location:
7p13
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44044702..44069456)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44203197..44227954)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44084301..44109055)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7454 Neighboring gene RAS p21 protein activator 4C, pseudogene Neighboring gene long intergenic non-protein coding RNA 957 Neighboring gene microRNA 6837 Neighboring gene phosphoglycerate mutase 2 Neighboring gene microRNA 6838 Neighboring gene DNA polymerase mu Neighboring gene AE binding protein 1 Neighboring gene microRNA 4649

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cadherin binding HDA PubMed 
enables enzyme activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in podosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in podosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
drebrin-like protein
Names
HPK1-interacting protein of 55 kDa
SH3 domain-containing protein 7
actin-binding protein 1
cervical SH3P7
cervical mucin-associated protein
drebrin-F
src homology 3 domain-containing protein HIP-55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014436.3NP_001014436.1  drebrin-like protein isoform b

    See identical proteins and their annotated locations for NP_001014436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC017116, AF077353, BC011677
    Consensus CDS
    CCDS34623.1
    UniProtKB/Swiss-Prot
    Q9NR72, Q9UJU6
    Related
    ENSP00000411701.1, ENST00000448521.6
    Conserved Domains (3) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:375428
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl27169
    Location:225374
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
  2. NM_001122956.2NP_001116428.1  drebrin-like protein isoform c

    See identical proteins and their annotated locations for NP_001116428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC017116, AK027367, BC011677, DC404852
    Consensus CDS
    CCDS47579.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000417653.1, ENST00000468694.5
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:384437
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  3. NM_001284313.2NP_001271242.1  drebrin-like protein isoform d

    See identical proteins and their annotated locations for NP_001271242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons, uses an alternate in-frame splice site and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform c.
    Source sequence(s)
    AC017116, AF218020, AK293698
    Consensus CDS
    CCDS64634.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000415173.1, ENST00000440166.5
    Conserved Domains (2) summary
    cd11960
    Location:272325
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl15697
    Location:135
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. NM_001284315.2NP_001271244.1  drebrin-like protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (e) has a shorter N-terminus compared to isoform c.
    Source sequence(s)
    AC017116, AF218020, AK300630
    Consensus CDS
    CCDS64633.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    UniProtKB/TrEMBL
    B4DUF9
    Related
    ENSP00000417749.2, ENST00000490734.6
    Conserved Domains (2) summary
    cd11960
    Location:281334
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
    cl15697
    Location:1543
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  5. NM_001362723.2NP_001349652.1  drebrin-like protein isoform f

    Status: VALIDATED

    Source sequence(s)
    AC017116, AK027367, BC011677, DC404852, DT220937
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:383436
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  6. NM_014063.7NP_054782.2  drebrin-like protein isoform a

    See identical proteins and their annotated locations for NP_054782.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC017116, BC011677, DC404852
    Consensus CDS
    CCDS34622.1
    UniProtKB/Swiss-Prot
    Q9UJU6
    Related
    ENSP00000419992.1, ENST00000494774.5
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:376429
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44044702..44069456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    44203197..44227954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)