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Dbnl drebrin-like [ Mus musculus (house mouse) ]

Gene ID: 13169, updated on 12-May-2024

Summary

Official Symbol
Dbnlprovided by MGI
Official Full Name
drebrin-likeprovided by MGI
Primary source
MGI:MGI:700006
See related
Ensembl:ENSMUSG00000020476 AllianceGenome:MGI:700006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abp1; SH3P7; mAbp1
Summary
Enables actin filament binding activity and protein domain specific binding activity. Involved in neuron projection morphogenesis; podosome assembly; and synapse assembly. Acts upstream of or within Rac protein signal transduction. Located in several cellular components, including lamellipodium; podosome; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 46.7), spleen adult (RPKM 43.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dbnl in Genome Data Viewer
Location:
11 A1; 11 3.87 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5730233..5750980)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5788483..5800980)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene upregulator of cell proliferation Neighboring gene STARR-seq mESC enhancer starr_28441 Neighboring gene STARR-positive B cell enhancer ABC_E8385 Neighboring gene ubiquitin-conjugating enzyme E2D, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6945 Neighboring gene STARR-seq mESC enhancer starr_28442 Neighboring gene phosphoglycerate mutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9815 Neighboring gene polymerase (DNA directed), mu

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within actin filament severing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
drebrin-like protein
Names
SH3 domain-containing protein 7
actin-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146308.1NP_001139780.1  drebrin-like protein isoform 1

    See identical proteins and their annotated locations for NP_001139780.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK134487, BM247511, BY293844
    Consensus CDS
    CCDS48746.1
    UniProtKB/Swiss-Prot
    Q3TG34, Q3U5X3, Q3U8I5, Q3UZ33, Q5NCI5, Q5NCI6, Q5NCI7, Q62418, Q80WP1, Q8BH56
    Related
    ENSMUSP00000020769.8, ENSMUST00000020769.14
    Conserved Domains (3) summary
    PRK13335
    Location:238341
    PRK13335; superantigen-like protein SSL3; Reviewed
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:381434
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  2. NM_001146309.1NP_001139781.1  drebrin-like protein isoform 3

    See identical proteins and their annotated locations for NP_001139781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in its 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK053796, BM247511, BY293844
    Consensus CDS
    CCDS48747.1
    UniProtKB/Swiss-Prot
    Q62418
    Related
    ENSMUSP00000105471.2, ENSMUST00000109845.8
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:377430
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
  3. NM_013810.3NP_038838.1  drebrin-like protein isoform 2

    See identical proteins and their annotated locations for NP_038838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK140752, BM247511, BY293844
    Consensus CDS
    CCDS24403.1
    UniProtKB/Swiss-Prot
    Q62418
    Related
    ENSMUSP00000099992.5, ENSMUST00000102928.5
    Conserved Domains (2) summary
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:378431
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5730233..5750980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156280.1XP_036012173.1  drebrin-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q3TG34, Q3U5X3, Q3U8I5, Q3UZ33, Q5NCI5, Q5NCI6, Q5NCI7, Q62418, Q80WP1, Q8BH56
    Conserved Domains (3) summary
    PRK13335
    Location:238341
    PRK13335; superantigen-like protein SSL3; Reviewed
    cd11281
    Location:3138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cd11960
    Location:381434
    SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1