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SLC27A6 solute carrier family 27 member 6 [ Homo sapiens (human) ]

Gene ID: 28965, updated on 1-Jun-2020

Summary

Official Symbol
SLC27A6provided by HGNC
Official Full Name
solute carrier family 27 member 6provided by HGNC
Primary source
HGNC:HGNC:11000
See related
Ensembl:ENSG00000113396 MIM:604196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FATP6; ACSVL2; FACVL2; VLCS-H1
Summary
This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 12.7), heart (RPKM 7.8) and 8 other tissues See more
Orthologs

Genomic context

See SLC27A6 in Genome Data Viewer
Location:
5q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (128965127..129033642)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (128300951..128369335)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379167 Neighboring gene uncharacterized LOC105379168 Neighboring gene uncharacterized LOC102723638 Neighboring gene microRNA 4633 Neighboring gene isochorismatase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779M0564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transport TAS
Traceable Author Statement
more info
 
very long-chain fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
long-chain fatty acid transport protein 6
Names
acyl-CoA synthetase very long chain family, member 2
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, very long-chain 2
solute carrier family 27 (fatty acid transporter), member 6
very long-chain acyl-CoA synthetase homolog 1
NP_001017372.1
NP_001304913.1
NP_054750.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017372.3NP_001017372.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_001017372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AL833117, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q9Y2P4
    Related
    ENSP00000262462.4, ENST00000262462.9
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  2. NM_001317984.1NP_001304913.1  long-chain fatty acid transport protein 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AA614135, AC004636, AF064254, AK313456, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q9Y2P4
    UniProtKB/TrEMBL
    B2R8P6
    Related
    ENSP00000421024.1, ENST00000506176.1
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated
  3. NM_014031.4NP_054750.1  long-chain fatty acid transport protein 6

    See identical proteins and their annotated locations for NP_054750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AA614135, AC004636, AF064254, BX537383
    Consensus CDS
    CCDS4145.1
    UniProtKB/Swiss-Prot
    Q9Y2P4
    Related
    ENSP00000378684.1, ENST00000395266.5
    Conserved Domains (2) summary
    cd05938
    Location:77609
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:16619
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    128965127..129033642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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