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GRB7 growth factor receptor bound protein 7 [ Homo sapiens (human) ]

Gene ID: 2886, updated on 5-Aug-2018

Summary

Official Symbol
GRB7provided by HGNC
Official Full Name
growth factor receptor bound protein 7provided by HGNC
Primary source
HGNC:HGNC:4567
See related
Ensembl:ENSG00000141738 MIM:601522; Vega:OTTHUMG00000133253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more
Orthologs

Genomic context

See GRB7 in Genome Data Viewer
Location:
17q12
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (39737901..39747285)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37894162..37903538)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene microRNA 4728 Neighboring gene migration and invasion enhancer 1 Neighboring gene IKAROS family zinc finger 3 Neighboring gene keratin 8 pseudogene 34 Neighboring gene ribosomal protein L39 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
    Angiopoietin receptor Tie2-mediated signaling
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • GRB7 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    GRB7 events in ERBB2 signaling, organism-specific biosystemHeterodimers of ERBB2 and ERBB3 are able to bind GRB7 (Fiddes et al. 1998) through phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1199 and Y1262), but the exact downstream signaling of thi...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
  • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    PDGFR-beta signaling pathway, organism-specific biosystem
    PDGFR-beta signaling pathway
  • RET signaling, organism-specific biosystem (from REACTOME)
    RET signaling, organism-specific biosystemThe RET proto-oncogene encodes a receptor tyrosine kinase expressed primarily in urogenital precursor cells, spermatogonocytes, dopaminergic neurons, motor neurons and neural crest progenitors and de...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by focal adhesion kinase, organism-specific biosystem
    Signaling events mediated by focal adhesion kinase
  • Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem
    Signaling events regulated by Ret tyrosine kinase
  • Tie2 Signaling, organism-specific biosystem (from REACTOME)
    Tie2 Signaling, organism-specific biosystemThe Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belong...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth factor receptor-bound protein 7
Names
B47
GRB7 adapter protein
epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029932.1 RefSeqGene

    Range
    5001..14377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001030002.2NP_001025173.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001025173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AU124875, BC006535
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    Q14451
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377761.3, OTTHUMP00000164350, ENST00000394211.7, OTTHUMT00000257025
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  2. NM_001242442.1NP_001229371.1  growth factor receptor-bound protein 7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (b).
    Source sequence(s)
    AC079199, AK125544, BC006535
    Consensus CDS
    CCDS56028.1
    UniProtKB/Swiss-Prot
    Q14451
    Related
    ENSP00000403459.2, OTTHUMP00000164352, ENST00000445327.6, OTTHUMT00000257029
    Conserved Domains (4) summary
    cd01787
    Location:123207
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:448555
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:248370
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:389433
    BPS; BPS (Between PH and SH2)
  3. NM_001242443.1NP_001229372.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001229372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK290115, BC006535
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    Q14451
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377759.2, OTTHUMP00000261082, ENST00000394209.6, OTTHUMT00000445640
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  4. NM_001330207.1NP_001317136.1  growth factor receptor-bound protein 7 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079199, BC006535
    Consensus CDS
    CCDS82116.1
    UniProtKB/Swiss-Prot
    Q14451
    Conserved Domains (3) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  5. NM_005310.3NP_005301.2  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_005301.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK222870, BC006535, DC384178
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    Q14451
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000310771.4, OTTHUMP00000164349, ENST00000309156.8, OTTHUMT00000257024
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    39737901..39747285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450729.1XP_024306497.1  growth factor receptor-bound protein 7 isoform X1

    Related
    ENSP00000377754.1, ENST00000394204.1
    Conserved Domains (3) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
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