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GRB7 growth factor receptor bound protein 7 [ Homo sapiens (human) ]

Gene ID: 2886, updated on 27-Nov-2024

Summary

Official Symbol
GRB7provided by HGNC
Official Full Name
growth factor receptor bound protein 7provided by HGNC
Primary source
HGNC:HGNC:4567
See related
Ensembl:ENSG00000141738 MIM:601522; AllianceGenome:HGNC:4567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues See more
Orthologs
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Genomic context

See GRB7 in Genome Data Viewer
Location:
17q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39737938..39747285)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40601500..40610848)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37894191..37903538)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37882556-37883528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8463 Neighboring gene microRNA 4728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37896451-37897048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37897647-37898244 Neighboring gene migration and invasion enhancer 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12108 Neighboring gene IKAROS family zinc finger 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37934634-37934867 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37940879-37941109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12110 Neighboring gene MPRA-validated peak2840 silencer Neighboring gene MPRA-validated peak2841 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37991649-37992148 Neighboring gene keratin 8 pseudogene 34 Neighboring gene ribosomal protein L39 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
NOT involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in negative regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth factor receptor-bound protein 7
Names
B47
GRB7 adapter protein
epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029932.2 RefSeqGene

    Range
    5002..14349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001030002.3NP_001025173.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001025173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377761.3, ENST00000394211.7
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  2. NM_001242442.2NP_001229371.2  growth factor receptor-bound protein 7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (b).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS56028.1
    Related
    ENSP00000403459.2, ENST00000445327.6
    Conserved Domains (4) summary
    cd10413
    Location:448555
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:248370
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16140
    Location:123210
    RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7
    pfam08947
    Location:389433
    BPS; BPS (Between PH and SH2)
  3. NM_001242443.2NP_001229372.1  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_001229372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000377759.2, ENST00000394209.6
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  4. NM_001330207.2NP_001317136.1  growth factor receptor-bound protein 7 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079199, BC006535
    Consensus CDS
    CCDS82116.1
    UniProtKB/Swiss-Prot
    Q14451
    Related
    ENSP00000377754.1, ENST00000394204.1
    Conserved Domains (3) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)
  5. NM_005310.5NP_005301.2  growth factor receptor-bound protein 7 isoform a

    See identical proteins and their annotated locations for NP_005301.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (a) is shorter at the N-terminus compared to isoform b. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC079199
    Consensus CDS
    CCDS11345.1
    UniProtKB/Swiss-Prot
    B2RAV1, B3KNL0, B3KWP9, B7WP75, J3KQM4, Q14451, Q53YD3, Q92568, Q96DF9, Q9Y220
    UniProtKB/TrEMBL
    A0A0S2Z4F6
    Related
    ENSP00000310771.4, ENST00000309156.9
    Conserved Domains (4) summary
    cd01787
    Location:100184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10413
    Location:425532
    SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
    cd01259
    Location:225347
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:366410
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    39737938..39747285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435857.1XP_047291813.1  growth factor receptor-bound protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    40601500..40610848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315868.1XP_054171843.1  growth factor receptor-bound protein 7 isoform X1