Grb7 growth factor receptor bound protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grb7provided by MGI
Official Full Name: growth factor receptor bound protein 7provided by MGI
Primary source: MGI:MGI:102683
See related: Ensembl:ENSMUSG00000019312 AllianceGenome:MGI:102683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4028
Summary: Predicted to enable identical protein binding activity; phosphatidylinositol binding activity; and protein kinase binding activity. Involved in negative regulation of translation and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GRB7 (growth factor receptor bound protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 50.8), liver adult (RPKM 48.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.75 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98337660..98346199)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98446834..98455373)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193.
Title: Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
Title: EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.
Grb7 is identified as an integral component of stress granules.
Title: Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.
The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation of kappa opioid receptor.
Title: The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GRB7_4323 (e-PCR)
- UniSTS:462897

M94450 (e-PCR)
- UniSTS:125004

NoName (e-PCR)
- UniSTS:236721

Grb7 (e-PCR), detects polymorphism
- UniSTS:548069

Homology

Homologs of the Grb7 gene: The Grb7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 315 organisms have orthologs with human gene Grb7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
NOT involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in stress granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth factor receptor-bound protein 7

Names: GRB7 adapter protein; Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7); epidermal growth factor receptor GRB-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010346.2 → NP_034476.1 growth factor receptor-bound protein 7

See identical proteins and their annotated locations for NP_034476.1

Status: VALIDATED

Source sequence(s)

AK168438, AW494536, CA496861

Consensus CDS

CCDS25351.1

UniProtKB/Swiss-Prot

Q03160, Q3TH55

UniProtKB/TrEMBL

A0A8C6MXC8

Related

ENSMUSP00000019456.5, ENSMUST00000019456.5

Conserved Domains (4) summary

cd10413
Location:428 → 535

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:224 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:102 → 186

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:369 → 413

BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98337660..98346199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532233.1 → XP_006532296.1 growth factor receptor-bound protein 7 isoform X1

See identical proteins and their annotated locations for XP_006532296.1

UniProtKB/Swiss-Prot

Q03160, Q3TH55

UniProtKB/TrEMBL

A0A8C6MXC8

Conserved Domains (4) summary

cd10413
Location:428 → 535

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:224 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:102 → 186

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:369 → 413

BPS; BPS (Between PH and SH2)
XM_030245575.1 → XP_030101435.1 growth factor receptor-bound protein 7 isoform X1

UniProtKB/Swiss-Prot

Q3TH55

UniProtKB/TrEMBL

A0A8C6MXC8

Conserved Domains (4) summary

cd10413
Location:428 → 535

SH2_Grb7; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins

cd01259
Location:224 → 350

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16140
Location:102 → 186

RA_GRB7; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 7

pfam08947
Location:369 → 413

BPS; BPS (Between PH and SH2)