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GPX5 glutathione peroxidase 5 [ Homo sapiens (human) ]

Gene ID: 2880, updated on 29-Mar-2018

Summary

Official Symbol
GPX5provided by HGNC
Official Full Name
glutathione peroxidase 5provided by HGNC
Primary source
HGNC:HGNC:4557
See related
Ensembl:ENSG00000224586 MIM:603435; Vega:OTTHUMG00000016307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL-S-75p
Summary
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
Expression
Restricted expression toward testis (RPKM 1.2) See more
Orthologs

Genomic context

See GPX5 in Genome Data Viewer
Location:
6p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (28526012..28534951)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28493789..28502728)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transfer RNA-Thr (CGT) 1-1 Neighboring gene glutathione peroxidase 6 Neighboring gene transfer RNA-Ile (TAT) 3-1 Neighboring gene uncharacterized LOC107986586 Neighboring gene transfer RNA-Arg (TCG) 5-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
sperm plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epididymal secretory glutathione peroxidase
Names
EGLP
GPx-5
GSHPx-5
epididymal androgen-related protein
epididymis secretory sperm binding protein Li 75p
epididymis-specific glutathione peroxidase-like protein
NP_001500.1
NP_003987.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047054.1 RefSeqGene

    Range
    5001..13940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001509.2NP_001500.1  epididymal secretory glutathione peroxidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ005277, AL049543, BX103177, DB336279
    Consensus CDS
    CCDS4652.1
    UniProtKB/Swiss-Prot
    O75715
    UniProtKB/TrEMBL
    V9HWN8
    Related
    ENSP00000392398.2, OTTHUMP00000017919, ENST00000412168.6, OTTHUMT00000043672
    Conserved Domains (1) summary
    cd00340
    Location:39211
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
  2. NM_003996.3NP_003987.2  epididymal secretory glutathione peroxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_003987.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon, which results in a frame-shift, compared to variant 1. The encoded isoform (2) is shorter, with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AJ005277, AL049543, BC128159, BX103177, DB336279
    Consensus CDS
    CCDS4653.1
    UniProtKB/Swiss-Prot
    O75715
    Related
    ENSP00000419935.1, OTTHUMP00000214636, ENST00000469384.1, OTTHUMT00000354292
    Conserved Domains (1) summary
    cl00388
    Location:4090
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_144470.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    DB024012, FJ460514

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    28526012..28534951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    15893..24832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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