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PPIL6 peptidylprolyl isomerase like 6 [ Homo sapiens (human) ]

Gene ID: 285755, updated on 23-Nov-2021

Summary

Official Symbol
PPIL6provided by HGNC
Official Full Name
peptidylprolyl isomerase like 6provided by HGNC
Primary source
HGNC:HGNC:21557
See related
Ensembl:ENSG00000185250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPIase; RSPH12; bA425D10.6; dJ919F19.1
Expression
Broad expression in testis (RPKM 2.1), thyroid (RPKM 1.7) and 18 other tissues See more
Orthologs
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Genomic context

See PPIL6 in Genome Data Viewer
Location:
6q21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (109390215..109441171, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109711418..109762374, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 162, pseudogene Neighboring gene uncharacterized LOC101927538 Neighboring gene CD164 molecule Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene ZBTB24 divergent transcript Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene adenylate kinase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27054, MGC27056, MGC41939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable inactive peptidyl-prolyl cis-trans isomerase-like 6
Names
cyclophilin-like protein PPIL6
peptidyl-prolyl cis-trans isomerase-like 6
peptidyl-prolyl cis-trans isomerase-like variant a
peptidylprolyl isomerase (cyclophilin)-like 6
problable inactive peptidyl-prolyl cis-trans isomerase-like 6
radial spoke 12 homolog
rotamase PPIL6
NP_001104768.2
NP_001273289.1
NP_001273290.1
NP_775943.1
XP_011534067.1
XP_011534068.1
XP_011534069.1
XP_011534071.1
XP_016866263.1
XP_024302175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111298.2NP_001104768.2  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 2

    See identical proteins and their annotated locations for NP_001104768.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional in-frame exon in the 3' coding region, compared to variant 1, resulting in a longer isoform (2), compared to isoform 1.
    Source sequence(s)
    AL359711, BQ012747, DQ423529
    Consensus CDS
    CCDS47466.2
    UniProtKB/Swiss-Prot
    Q8IXY8
    Related
    ENSP00000392257.2, ENST00000440797.6
    Conserved Domains (1) summary
    cl00197
    Location:144333
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  2. NM_001286360.1NP_001273289.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 3

    See identical proteins and their annotated locations for NP_001273289.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AI052546, AL359711, BQ012747, DA413621, DQ363562
    Consensus CDS
    CCDS69169.1
    UniProtKB/Swiss-Prot
    Q8IXY8
    Related
    ENSP00000407731.2, ENST00000424445.6
    Conserved Domains (1) summary
    cl00197
    Location:112275
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  3. NM_001286361.1NP_001273290.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 4

    See identical proteins and their annotated locations for NP_001273290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL109947, AL359711, BI824055, BQ012747, DA413621, DQ363562
    UniProtKB/Swiss-Prot
    Q8IXY8
    Related
    ENSP00000427899.1, ENST00000520723.5
    Conserved Domains (1) summary
    cl00197
    Location:95197
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  4. NM_173672.5NP_775943.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 1

    See identical proteins and their annotated locations for NP_775943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL109947, AL359711
    Consensus CDS
    CCDS5074.1
    UniProtKB/Swiss-Prot
    Q8IXY8
    Related
    ENSP00000427929.1, ENST00000521072.7
    Conserved Domains (1) summary
    cl00197
    Location:144307
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RNA

  1. NR_104429.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK293674, AL359711, BQ012747, DQ363562

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    109390215..109441171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010774.1XP_016866263.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X6

    Related
    ENSP00000389292.3, ENST00000447468.7
    Conserved Domains (1) summary
    cl00197
    Location:127229
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  2. XM_011535765.3XP_011534067.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X1

    Conserved Domains (1) summary
    cl00197
    Location:112301
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  3. XM_011535766.3XP_011534068.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X2

    Conserved Domains (1) summary
    cl00197
    Location:127230
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  4. XM_011535767.3XP_011534069.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X3

    Conserved Domains (1) summary
    cl00197
    Location:127234
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  5. XM_024446407.1XP_024302175.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X5

    Conserved Domains (1) summary
    cl00197
    Location:95202
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  6. XM_011535769.2XP_011534071.1  probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform X4

    Conserved Domains (1) summary
    cl00197
    Location:127229
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
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