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DTWD2 DTW domain containing 2 [ Homo sapiens (human) ]

Gene ID: 285605, updated on 6-Sep-2022

Summary

Official Symbol
DTWD2provided by HGNC
Official Full Name
DTW domain containing 2provided by HGNC
Primary source
HGNC:HGNC:19334
See related
Ensembl:ENSG00000169570 AllianceGenome:HGNC:19334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in tRNA modification. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 4.3), kidney (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

See DTWD2 in Genome Data Viewer
Location:
5q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (118836074..118988547, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (119349130..119501614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (118171769..118324242, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901052 Neighboring gene RNA, U7 small nuclear 34 pseudogene Neighboring gene microRNA 1244-2 Neighboring gene prothymosin alpha pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene N-acetylneuraminic acid phosphatase pseudogene Neighboring gene cation channel sperm associated 2 pseudogene Neighboring gene DMXL1 divergent transcript

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33977, MGC138579, MGC138580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tRNA-uridine aminocarboxypropyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-uridine aminocarboxypropyltransferase 2
Names
DTW domain-containing protein 2
NP_001295010.1
NP_775937.1
XP_011541640.3
XP_011541642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308081.2NP_001295010.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform b

    See identical proteins and their annotated locations for NP_001295010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC010462, AW009893, BX648369
    Consensus CDS
    CCDS78050.1
    UniProtKB/TrEMBL
    J3KND6
    Related
    ENSP00000302892.4, ENST00000304058.8
    Conserved Domains (1) summary
    pfam03942
    Location:7186
    DTW; DTW domain
  2. NM_173666.4NP_775937.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_775937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010462, AW009893, BC114508, HY055818
    Consensus CDS
    CCDS34216.1
    UniProtKB/Swiss-Prot
    J3KND6, Q8NBA8
    Related
    ENSP00000425048.1, ENST00000510708.6
    Conserved Domains (1) summary
    pfam03942
    Location:66256
    DTW; DTW domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    118836074..118988547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543338.4XP_011541640.3  tRNA-uridine aminocarboxypropyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam03942
    Location:66276
    DTW; DTW domain
  2. XM_011543340.3XP_011541642.1  tRNA-uridine aminocarboxypropyltransferase 2 isoform X2

    Conserved Domains (1) summary
    pfam03942
    Location:7210
    DTW; DTW domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    119349130..119501614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)