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STPG4 sperm-tail PG-rich repeat containing 4 [ Homo sapiens (human) ]

Gene ID: 285051, updated on 6-Sep-2022

Summary

Official Symbol
STPG4provided by HGNC
Official Full Name
sperm-tail PG-rich repeat containing 4provided by HGNC
Primary source
HGNC:HGNC:26850
See related
Ensembl:ENSG00000239605 AllianceGenome:HGNC:26850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSE; C2orf61
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in DNA demethylation of male pronucleus and positive regulation of DNA demethylation. Predicted to act upstream of or within C-5 methylation of cytosine. Predicted to be located in cytoplasm and nucleus. Predicted to be active in female pronucleus; germinal vesicle; and male pronucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 2.2) See more
Orthologs
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Genomic context

See STPG4 in Genome Data Viewer
Location:
2p21
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (47086991..47155308, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (47091740..47160427, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (47314130..47382447, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7A Neighboring gene Sharpr-MPRA regulatory region 1272/3994 Neighboring gene VISTA enhancer hs1967 Neighboring gene calmodulin 2 Neighboring gene EPCAM divergent transcript Neighboring gene uncharacterized LOC105374588

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CALM2

Homology

Clone Names

  • FLJ40172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in C-5 methylation of cytosine IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA demethylation of male pronucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA demethylation of male pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA demethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in female pronucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in female pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in germinal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in germinal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in male pronucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in male pronucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein STPG4
Names
gonad-specific expression gene protein
sperm-tail PG-rich repeat-containing protein 4
uncharacterized protein C2orf61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163561.2NP_001157033.1  protein STPG4 isoform 1

    See identical proteins and their annotated locations for NP_001157033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073283
    Consensus CDS
    CCDS54356.1
    UniProtKB/Swiss-Prot
    H7C2Z2, Q8N801
    Related
    ENSP00000408527.2, ENST00000445927.7
  2. NM_173649.3NP_775920.1  protein STPG4 isoform 2

    See identical proteins and their annotated locations for NP_775920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073283, AK097491, DA313162
    Consensus CDS
    CCDS1831.1
    UniProtKB/Swiss-Prot
    Q8N801
    Related
    ENSP00000294947.2, ENST00000294947.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    47086991..47155308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    47091740..47160427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)