Format

Send to:

Choose Destination

GPR25 G protein-coupled receptor 25 [ Homo sapiens (human) ]

Gene ID: 2848, updated on 18-Aug-2020

Summary

Official Symbol
GPR25provided by HGNC
Official Full Name
G protein-coupled receptor 25provided by HGNC
Primary source
HGNC:HGNC:4480
See related
Ensembl:ENSG00000170128 MIM:602174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]
Orthologs

Genomic context

See GPR25 in Genome Data Viewer
Location:
1q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (200872981..200874178)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200842083..200843306)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin associated protein family member 2 Neighboring gene ribosomal protein L34 pseudogene 6 Neighboring gene uncharacterized LOC107985245 Neighboring gene innate immunity activator

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human G protein-coupled receptor 25 (GPR25) at amino acid residues 315-316 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005298.4NP_005289.2  probable G-protein coupled receptor 25

    See identical proteins and their annotated locations for NP_005289.2

    Status: REVIEWED

    Source sequence(s)
    BC126386
    Consensus CDS
    CCDS1405.1
    UniProtKB/Swiss-Prot
    O00155
    Related
    ENSP00000301917.2, ENST00000304244.5
    Conserved Domains (1) summary
    pfam00001
    Location:56307
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    200872981..200874178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center