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ZNF326 zinc finger protein 326 [ Homo sapiens (human) ]

Gene ID: 284695, updated on 5-Jul-2020

Summary

Official Symbol
ZNF326provided by HGNC
Official Full Name
zinc finger protein 326provided by HGNC
Primary source
HGNC:HGNC:14104
See related
Ensembl:ENSG00000162664 MIM:614601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIRD; ZAN75; Zfp326; dJ871E2.1
Expression
Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF326 in Genome Data Viewer
Location:
1p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89995095..90035533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (90460678..90494101)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 272 Neighboring gene gem nuclear organelle associated protein 8 pseudogene 4 Neighboring gene uncharacterized LOC105378848 Neighboring gene uncharacterized LOC105378849 Neighboring gene RNA, U6 small nuclear 695, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Zinc finger protein 326 (ZNF326) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20403, MGC61591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
DBIRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DBIRD complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
DBIRD complex subunit ZNF326
Names
ZNF-protein interacting with nuclear mRNPs and DBC1
dJ871E2.1 (novel protein (ortholog of mouse zinc finger protein Zan75))
zinc finger protein interacting with mRNPs and DBC1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320185.2NP_001307114.1  DBIRD complex subunit ZNF326 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK303707, AL161797, BC014899, BU676987, CN299618
    Consensus CDS
    CCDS81351.1
    UniProtKB/Swiss-Prot
    Q5BKZ1
    UniProtKB/TrEMBL
    A0A0A0MRN4
    Related
    ENSP00000359476.2, ENST00000370447.3
    Conserved Domains (1) summary
    pfam04988
    Location:223388
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
  2. NM_181781.4NP_861446.2  DBIRD complex subunit ZNF326 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303707, AL161797, BC014899, BC038454, BU676987, CN299618
    UniProtKB/Swiss-Prot
    Q5BKZ1
    Conserved Domains (1) summary
    pfam04988
    Location:106271
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
  3. NM_182975.3NP_892020.1  DBIRD complex subunit ZNF326 isoform 3

    See identical proteins and their annotated locations for NP_892020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon structure and differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK000410, BC053888, CN299618
    Consensus CDS
    CCDS728.1
    UniProtKB/Swiss-Prot
    Q5BKZ1
    Related
    ENSP00000355318.5, ENST00000361911.9
  4. NM_182976.4NP_892021.1  DBIRD complex subunit ZNF326 isoform 1

    See identical proteins and their annotated locations for NP_892021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK303707, AL161797, BC090866, BU676987, CN299618
    Consensus CDS
    CCDS727.1
    UniProtKB/Swiss-Prot
    Q5BKZ1
    Related
    ENSP00000340796.4, ENST00000340281.9
    Conserved Domains (1) summary
    pfam04988
    Location:312477
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89995095..90035533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541290.2XP_011539592.1  DBIRD complex subunit ZNF326 isoform X1

    See identical proteins and their annotated locations for XP_011539592.1

    UniProtKB/Swiss-Prot
    Q5BKZ1
    Conserved Domains (1) summary
    pfam04988
    Location:106271
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
  2. XM_005270779.4XP_005270836.1  DBIRD complex subunit ZNF326 isoform X1

    See identical proteins and their annotated locations for XP_005270836.1

    UniProtKB/Swiss-Prot
    Q5BKZ1
    Conserved Domains (1) summary
    pfam04988
    Location:106271
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
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